AMBRA1

AMBRA1
Identifiers
Aliases	AMBRA1, DCAF3, WDR94, autophagy and beclin 1 regulator 1
External IDs	OMIM: 611359; MGI: 2443564; HomoloGene: 18204; GeneCards: AMBRA1; OMA:AMBRA1 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	46,594,125 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	91,749,194 bp
RNA expression pattern
	Top expressed in
	oocyte; ; secondary oocyte; ; vena cava; ; tendon of biceps brachii; ; nipple; ; mucosa of pharynx; ; cerebellar vermis; ; cardia; ; ventral tegmental area; ; thymus;
	Top expressed in
	zygote; ; primary oocyte; ; lateral septal nucleus; ; habenula; ; subiculum; ; mammillary body; ; cerebellar vermis; ; anterior amygdaloid area; ; lateral geniculate nucleus; ; lobe of cerebellum;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding; ubiquitin protein ligase binding; GTPase binding;
Cellular component	cytoplasm; autophagosome; mitochondrial outer membrane; phagocytic vesicle; mitochondrion; perinuclear region of cytoplasm; axoneme; cytoplasmic vesicle; cytosol;
Biological process	negative regulation of neuron apoptotic process; cell differentiation; nervous system development; positive regulation of phosphatidylinositol 3-kinase activity; autophagy; multicellular organism development; neural tube development; macroautophagy; negative regulation of cell population proliferation; cellular response to starvation; positive regulation of autophagy; negative regulation of cardiac muscle cell apoptotic process; response to nutrient levels; autophagosome assembly; autophagy of mitochondrion; mitophagy; response to mitochondrial depolarisation;
	Sources:Amigo / QuickGO
Orthologs
	55626
	228361
	ENSG00000110497
	ENSMUSG00000040506
	Q9C0C7
	A2AH22
NM_001267782; NM_001267783; NM_001300731; NM_017749; NM_001367468;
	NM_001367469; NM_001367470; NM_001367471; NM_001387011
	NM_001080754; NM_172669
NP_001254711; NP_001254712; NP_001287660; NP_060219; NP_001354397;
	NP_001354398; NP_001354399; NP_001354400
	NP_001074223; NP_766257
	Wikidata
View/Edit Human	View/Edit Mouse

AMBRA1 (activating molecule in Beclin1-regulated autophagy) is a protein that is able to regulate cancer cells through autophagy. AMBRA1 is described as a mechanism cells use to divide and there is new evidence demonstrating the role and impact of AMBRA1 as a candidate for the treatment of several disorders and diseases, including anticancer therapy. It is known to suppress tumors and plays a role in mitophagy and apoptosis. AMBRA1 can be found in the cytoskeleton and mitochondria and during the process of autophagy, it is localized at the endoplasmic reticulum. In normal conditions, AMBRA1 is dormant and will bind to BCL2 in the outer membrane. This relocation enables autophagosome nucleation. AMBRA1 protein is involved in several cellular processes and is involved in the regulation of the immune system and nervous system.