AMY1A

AMY1A
Available structures
PDB	Human UniProt search: PDBe RCSB
List of PDB id codes
	1C8Q, 1JXJ, 1JXK, 1MFU, 1MFV, 1NM9, 1Q4N, 1SMD, 1XV8, 1Z32, 3BLK, 3BLP, 3DHP
Identifiers
Aliases	AMY1A, AMY1, amylase, alpha 1A (salivary), amylase alpha 1A (salivary), amylase alpha 1A
External IDs	OMIM: 104700; HomoloGene: 133998; GeneCards: AMY1A; OMA:AMY1A - orthologs
EC number	3.2.1.1
Gene location (Human)
Chr.	Chromosome 1 (human)
End	103,664,554 bp
RNA expression pattern
	Top expressed in
	body of pancreas; ; testicle; ; right uterine tube; ; gonad; ; olfactory zone of nasal mucosa; ; tonsil; ; right lobe of thyroid gland; ; placenta; ; left lobe of thyroid gland; ; salivary gland;
	n/a
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding; alpha-amylase activity; hydrolase activity; catalytic activity; metal ion binding; hydrolase activity, acting on glycosyl bonds; cation binding;
Cellular component	extracellular region; extracellular exosome; extracellular space;
Biological process	digestion; metabolism; carbohydrate metabolic process;
	Sources:Amigo / QuickGO
Orthologs
	276
	n/a
	ENSG00000237763
	n/a
	P04745
	n/a
	NM_004038; NM_001008221
	n/a
	NP_001008220; NP_001333709; NP_001008222; NP_004029; NP_001008219
	n/a
	Wikidata
View/Edit Human

Alpha-amylase 1 is an enzyme that in humans is encoded by the polich gene. This gene is found in many organisms.

Amylases are secreted proteins that hydrolyze 1,4-alpha-glucoside bonds in oligosaccharides and polysaccharides, and thus catalyze the first step in digestion of dietary starch and glycogen. The human genome has a cluster of several amylase genes that are expressed at high levels in either salivary gland or pancreas. This gene encodes an amylase isoenzyme produced by the salivary gland. Alternative splicing results in multiple transcript variants encoding the same protein.