AMY2A

AMY2A
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1B2Y, 1BSI, 1CPU, 1HNY, 1KB3, 1KBB, 1KBK, 1KGU, 1KGW, 1KGX, 1U2Y, 1U30, 1U33, 1XCW, 1XCX, 1XD0, 1XD1, 1XGZ, 1XH0, 1XH1, 1XH2, 2CPU, 2QMK, 2QV4, 3BAI, 3BAJ, 3BAK, 3BAW, 3BAX, 3BAY, 3CPU, 3IJ7, 3IJ8, 3IJ9, 3OLD, 3OLE, 3OLG, 3OLI, 4GQQ, 4GQR, 4W93, 4X9Y, 5EMY
Identifiers
Aliases	AMY2A, AMY2, AMY2B, PA, amylase, alpha 2A (pancreatic), amylase alpha 2A (pancreatic), amylase alpha 2A
External IDs	OMIM: 104650; MGI: 88019; HomoloGene: 20179; GeneCards: AMY2A; OMA:AMY2A - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	103,625,780 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	113,400,348 bp
RNA expression pattern
	Top expressed in
	body of pancreas; ; islet of Langerhans; ; duodenum; ; testicle; ; nucleus accumbens; ; fundus; ; ectocervix; ; putamen; ; caudate nucleus; ; right lobe of liver;
	Top expressed in
	parotid gland; ; lacrimal gland; ; submandibular gland; ; intercostal muscle; ; left lobe of liver; ; white adipose tissue; ; neural layer of retina; ; tunica adventitia of aorta; ; subcutaneous adipose tissue; ; lactiferous gland;
	More reference expression data
	n/a
Gene ontology
Molecular function	chloride ion binding; calcium ion binding; catalytic activity; alpha-amylase activity; hydrolase activity; metal ion binding; hydrolase activity, acting on glycosyl bonds; cation binding;
Cellular component	extracellular region; extracellular exosome; extracellular space;
Biological process	carbohydrate catabolic process; polysaccharide digestion; metabolism; carbohydrate metabolic process;
	Sources:Amigo / QuickGO
Orthologs
	279
	11722
	ENSG00000243480
	ENSMUSG00000074264
	P04746
	P00687
	NM_000699
	NM_001110505; NM_007446
	NP_000690
	NP_001103975; NP_031472
	Wikidata
View/Edit Human	View/Edit Mouse

Pancreatic alpha-amylase is an enzyme that in humans is encoded by the AMY2A gene.

Amylases are secreted proteins that hydrolyze 1,4-alpha-glucoside bonds in oligosaccharides and polysaccharides, and thus catalyze the first step in digestion of dietary starch and glycogen. The human genome has a cluster of several amylase genes that are expressed at high levels in either salivary gland or pancreas. This gene encodes an amylase isoenzyme produced by the pancreas.