ANAPC4

ANAPC4
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4UI9, 5BPW, 5A31, 5G05, 5G04
Identifiers
Aliases	ANAPC4, APC4, anaphase promoting complex subunit 4
External IDs	OMIM: 606947; MGI: 1098673; HomoloGene: 40873; GeneCards: ANAPC4; OMA:ANAPC4 - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	25,418,498 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	53,025,139 bp
RNA expression pattern
	Top expressed in
	right uterine tube; ; endometrium; ; tendon of biceps brachii; ; germinal epithelium; ; bronchial epithelial cell; ; parietal pleura; ; visceral pleura; ; Brodmann area 23; ; thymus; ; tibia;
	Top expressed in
	primary oocyte; ; neural layer of retina; ; superior cervical ganglion; ; ventricular zone; ; pituitary gland; ; vas deferens; ; ganglionic eminence; ; limb bud; ; fossa; ; condyle;
	More reference expression data
	n/a
Gene ontology
Molecular function	ubiquitin-protein transferase activity; protein phosphatase binding; protein binding; ubiquitin protein ligase activity;
Cellular component	anaphase-promoting complex; cytosol; nucleus; nucleoplasm; nuclear periphery;
Biological process	anaphase-promoting complex-dependent catabolic process; regulation of mitotic metaphase/anaphase transition; cell division; protein K11-linked ubiquitination; cell cycle; protein ubiquitination; positive regulation of mitotic metaphase/anaphase transition; regulation of mitotic cell cycle phase transition; ubiquitin-dependent protein catabolic process;
	Sources:Amigo / QuickGO
Orthologs
	29945
	52206
	ENSG00000053900
	ENSMUSG00000029176
	Q9UJX5
	Q91W96
	NM_001286756; NM_013367
	NM_024213
	NP_001273685; NP_037499
	NP_077175
	Wikidata
View/Edit Human	View/Edit Mouse

Anaphase-promoting complex subunit 4 is an enzyme that in humans is encoded by the ANAPC4 gene.

A large protein complex, termed the anaphase-promoting complex (APC), or the cyclosome, promotes metaphase-anaphase transition by ubiquitinating its specific substrates such as mitotic cyclins and anaphase inhibitor, which are subsequently degraded by the 26S proteasome. Biochemical studies have shown that the vertebrate APC contains eight subunits. The composition of the APC is highly conserved in organisms from yeast to humans. The exact function of this gene product is not known.