ANGPT4

ANGPT4
Identifiers
Aliases	ANGPT4, AGP4, ANG-3, ANG4, ANG3, angiopoietin 4
External IDs	OMIM: 603705; MGI: 1336887; HomoloGene: 36302; GeneCards: ANGPT4; OMA:ANGPT4 - orthologs
Gene location (Human)
Chr.	Chromosome 20 (human)
End	916,334 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	151,787,257 bp
RNA expression pattern
	Top expressed in
	subcutaneous adipose tissue; ; left uterine tube; ; right ovary; ; canal of the cervix; ; popliteal artery; ; tibial arteries; ; body of uterus; ; left ovary; ; ectocervix; ; right coronary artery;
	Top expressed in
	decidua; ; stroma of bone marrow; ; gastrula; ; body of femur; ; lip; ; molar; ; efferent ductule; ; vas deferens; ; skin of external ear; ; abdominal wall;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	receptor tyrosine kinase binding; transmembrane receptor protein tyrosine kinase activator activity;
Cellular component	extracellular region; extracellular space;
Biological process	Notch signaling pathway; positive regulation of endothelial cell migration; negative regulation of angiogenesis; negative regulation of apoptotic process; negative regulation of blood vessel endothelial cell migration; cellular response to hypoxia; endothelial cell proliferation; angiogenesis; positive regulation of blood vessel endothelial cell migration; leukocyte migration; positive regulation of angiogenesis; positive regulation of peptidyl-tyrosine phosphorylation; activation of transmembrane receptor protein tyrosine kinase activity;
	Sources:Amigo / QuickGO
Orthologs
	51378
	11602
	ENSG00000101280
	ENSMUSG00000027460
	Q9Y264
	Q9WVH6
	NM_015985; NM_001322809
	NM_009641
	NP_001309738; NP_057069
	NP_033771
	Wikidata
View/Edit Human	View/Edit Mouse

Angiopoietin-4 is a protein that in humans is encoded by the ANGPT4 gene.

Angiopoietins are proteins with important roles in vascular development and angiogenesis. All angiopoietins bind with similar affinity to an endothelial cell-specific tyrosine-protein kinase receptor. The mechanism by which they contribute to angiogenesis is thought to involve regulation of endothelial cell interactions with supporting perivascular cells.

The protein encoded by this gene functions as an agonist and is an angiopoietin.