ANKRD1

ANKRD1
Identifiers
Aliases	ANKRD1, ALRP, C-193, CARP, CVARP, MCARP, bA320F15.2, ankyrin repeat domain 1
External IDs	OMIM: 609599; MGI: 1097717; HomoloGene: 8289; GeneCards: ANKRD1; OMA:ANKRD1 - orthologs
Gene location (Human)
Chr.	Chromosome 10 (human)
End	90,921,087 bp
RNA expression pattern
	Top expressed in
	apex of heart; ; right auricle of heart; ; left ventricle; ; myocardium of left ventricle; ; right lung; ; vena cava; ; muscle of thigh; ; cardiac muscle tissue of right atrium; ; gastrocnemius muscle; ; glutes;
	n/a
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA binding; transcription coactivator activity; R-SMAD binding; transcription corepressor activity; p53 binding; histone deacetylase binding; titin binding; protein binding; RNA polymerase II-specific DNA-binding transcription factor binding; transcription factor binding;
Cellular component	cytoplasm; cytosol; transcription regulator complex; nucleoplasm; myofibril; nucleus; fibrillar center; I band;
Biological process	response to muscle stretch; cellular response to transforming growth factor beta stimulus; regulation of transcription by RNA polymerase II; cellular response to tumor necrosis factor; cellular response to organic cyclic compound; cardiac muscle tissue morphogenesis; negative regulation of transcription by RNA polymerase II; cellular response to mechanical stimulus; cellular response to interleukin-1; positive regulation of protein secretion; positive regulation of neuron projection development; positive regulation of apoptotic process; positive regulation of DNA damage response, signal transduction by p53 class mediator; cellular response to lipopolysaccharide; sarcomere organization; cellular response to hypoxia; negative regulation of DNA biosynthetic process; positive regulation of transcription by RNA polymerase II; regulation of lipid metabolic process; skeletal muscle cell differentiation; myoblast differentiation; transcription by RNA polymerase II; positive regulation of nucleic acid-templated transcription; skeletal muscle tissue development;
	Sources:Amigo / QuickGO
Orthologs
	27063
	107765
	ENSG00000148677
	ENSMUSG00000024803
	Q15327
	Q9CR42
	NM_014391
	NM_013468
	NP_055206
	NP_038496
	Wikidata
View/Edit Human	View/Edit Mouse

Ankyrin repeat domain-containing protein 1, or Cardiac ankyrin repeat protein is a protein that in humans is encoded by the ANKRD1 gene also known as CARP. CARP is highly expressed in cardiac and skeletal muscle, and is a transcription factor involved in development and under conditions of stress. CARP has been implicated in several diseases, including dilated cardiomyopathy, hypertrophic cardiomyopathy, and several skeletal muscle myopathies.