ANKS1A

ANKS1A
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2LMR, 2MYQ
Identifiers
Aliases	ANKS1A, ANKS1, ankyrin repeat and sterile alpha motif domain containing 1A
External IDs	OMIM: 608994; MGI: 2446180; HomoloGene: 9068; GeneCards: ANKS1A; OMA:ANKS1A - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	35,091,406 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	28,281,749 bp
RNA expression pattern
	Top expressed in
	olfactory bulb; ; trigeminal ganglion; ; spinal ganglia; ; seminal vesicula; ; endothelial cell; ; saphenous vein; ; paraflocculus of cerebellum; ; bronchial epithelial cell; ; amniotic fluid; ; mucosa of urinary bladder;
	Top expressed in
	interventricular septum; ; granulocyte; ; neural layer of retina; ; lip; ; utricle; ; vestibular membrane of cochlear duct; ; myocardium of ventricle; ; cerebellar cortex; ; cardiac muscles; ; sciatic nerve;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; ephrin receptor binding;
Cellular component	neuron projection; cell projection; nucleoplasm; cytoplasm; cytosol;
Biological process	ephrin receptor signaling pathway; neuron remodeling; substrate-dependent cell migration; regulation of ephrin receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	23294
	224650
	ENSG00000064999
	ENSMUSG00000024219
	Q92625
	P59672
	NM_015245
	NM_001286040; NM_001286041; NM_181413; NM_001374802
	NP_056060
	NP_001272969; NP_001272970; NP_852078
	Wikidata
View/Edit Human	View/Edit Mouse

Ankyrin repeat and SAM domain-containing protein 1A (ANKS1A), also known as ODIN, is a protein that in humans is encoded by the ANKS1A gene on chromosome 6.

It is ubiquitously expressed in many tissues and cell types. ODIN is known to regulate the epidermal growth factor receptor (EGFR) and EphA receptor signaling pathways. As a Src family kinase target, ODIN has been implicated in the development of cancer. The ANKS1A gene also contains one of 27 SNPs associated with increased risk of coronary artery disease.