ANO1

ANO1
Identifiers
Aliases	ANO1, DOG1, ORAOV2, TAOS2, TMEM16A, anoctamin 1
External IDs	OMIM: 610108; MGI: 2142149; HomoloGene: 75079; GeneCards: ANO1; OMA:ANO1 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	70,189,530 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	144,305,711 bp
RNA expression pattern
	Top expressed in
	caput epididymis; ; seminal vesicula; ; corpus epididymis; ; parotid gland; ; ascending aorta; ; gallbladder; ; Descending thoracic aorta; ; gastric mucosa; ; tail of epididymis; ; right coronary artery;
	Top expressed in
	parotid gland; ; gastrula; ; wall of urinary bladder; ; mucosa of urinary bladder; ; transitional epithelium of urinary bladder; ; left colon; ; submandibular gland; ; decidua; ; seminal vesicula; ; lacrimal gland;
	More reference expression data
	n/a
Gene ontology
Molecular function	calcium activated cation channel activity; protein dimerization activity; protein binding; voltage-gated chloride channel activity; chloride channel activity; iodide transmembrane transporter activity; intracellular calcium activated chloride channel activity;
Cellular component	cytoplasm; integral component of membrane; membrane; plasma membrane; chloride channel complex; apical plasma membrane; extracellular exosome;
Biological process	cation transport; ion transport; detection of temperature stimulus involved in sensory perception of pain; multicellular organism development; phospholipase C-activating G protein-coupled receptor signaling pathway; ion transmembrane transport; iodide transport; chloride transport; cation transmembrane transport; regulation of anion transmembrane transport; transport; cellular response to heat; positive regulation of insulin secretion involved in cellular response to glucose stimulus; chloride transmembrane transport;
	Sources:Amigo / QuickGO
Orthologs
	55107
	101772
	ENSG00000131620
	ENSMUSG00000031075
	Q5XXA6
	Q8BHY3
NM_018043; NM_001378092; NM_001378093; NM_001378094; NM_001378095;
	NM_001378096; NM_001378097
	NM_001242349; NM_178642
NP_060513; NP_001365021; NP_001365022; NP_001365023; NP_001365024;
	NP_001365025; NP_001365026
	NP_001229278; NP_848757
	Wikidata
View/Edit Human	View/Edit Mouse

Anoctamin-1 (ANO1), also known as Transmembrane member 16A (TMEM16A), is a protein that, in humans, is encoded by the ANO1 gene. Anoctamin-1 is a voltage-gated calcium-activated anion channel, which acts as a chloride channel and a bicarbonate channel. additionally Anoctamin-1 is apical iodide channel.

It is expressed in smooth muscle, epithelial cells, vomeronasal neurons, olfactory sustentacular cells, and is highly expressed in interstitial cells of Cajal (ICC) throughout the gastrointestinal tract.