ANP32E

ANP32E
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4CAY, 4NFT
Identifiers
Aliases	ANP32E, LANP-L, LANPL, acidic nuclear phosphoprotein 32 family member E
External IDs	OMIM: 609611; MGI: 1913721; HomoloGene: 137403; GeneCards: ANP32E; OMA:ANP32E - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	150,236,156 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	95,854,702 bp
RNA expression pattern
	Top expressed in
	trabecular bone; ; caput epididymis; ; corpus epididymis; ; dorsal motor nucleus of vagus nerve; ; ventricular zone; ; epithelium of nasopharynx; ; retinal pigment epithelium; ; tail of epididymis; ; Epithelium of choroid plexus; ; gingival epithelium;
	Top expressed in
	tail of embryo; ; neural layer of retina; ; genital tubercle; ; otic vesicle; ; pineal gland; ; otic placode; ; cumulus cell; ; saccule; ; ventricular zone; ; abdominal wall;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	histone binding; phosphatase inhibitor activity;
Cellular component	cytoplasm; nucleus; Swr1 complex; cytoplasmic vesicle;
Biological process	negative regulation of catalytic activity; histone exchange; nucleosome assembly; nucleocytoplasmic transport; regulation of apoptotic process; chromatin organization;
	Sources:Amigo / QuickGO
Orthologs
	81611
	66471
	ENSG00000143401
	ENSMUSG00000015749
	Q9BTT0
	P97822
	NM_001136478; NM_001136479; NM_001280559; NM_001280560; NM_030920
	NM_001253757; NM_001253758; NM_023210
	NP_001129950; NP_001129951; NP_001267488; NP_001267489; NP_112182
	NP_001240686; NP_001240687; NP_075699
	Wikidata
View/Edit Human	View/Edit Mouse

Acidic leucine-rich nuclear phosphoprotein 32 family member E is a protein that in humans is encoded by the ANP32E gene. The ANP32E gene is located on chromosome 1q22. In mammalian cells, ANP32E has been shown to be an H2A.Z chaperone capable of promoting the removal of H2A.Z from chromatin. In brain tissue, ANP32E together with Cpd1 regulate protein phosphatase 2A activity at synapses during synaptogenesis and has been observed to form a complex with ANP32A and SET that stabilizes short-lived mRNAs containing AU-rich elements, as well as having acetyltransferase inhibitory activity (in a complex with SET) and having a role in chromatin remodeling and transcriptional regulation.