Annexin A2

ANXA2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1W7B, 1XJL, 2HYU, 2HYV, 2HYW, 4DRW, 4FTG, 4HRH
Identifiers
Aliases	ANXA2, ANX2, ANX2L4, CAL1H, HEL-S-270, LIP2, LPC2, LPC2D, P36, PAP-IV, annexin A2
External IDs	OMIM: 151740; MGI: 88246; HomoloGene: 20857; GeneCards: ANXA2; OMA:ANXA2 - orthologs
Gene location (Human)
Chr.	Chromosome 15 (human)
End	60,402,883 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	69,399,077 bp
RNA expression pattern
	Top expressed in
	bronchial epithelial cell; ; amniotic fluid; ; nasal epithelium; ; epithelium of nasopharynx; ; synovial joint; ; mucosa of pharynx; ; visceral pleura; ; parietal pleura; ; oral cavity; ; hair follicle;
	Top expressed in
	corneal stroma; ; endothelial cell of lymphatic vessel; ; granulocyte; ; gastrula; ; calvaria; ; skin of external ear; ; dermis; ; umbilical cord; ; conjunctival fornix; ; right lung lobe;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	phospholipase inhibitor activity; calcium ion binding; S100 protein binding; phospholipase A2 inhibitor activity; calcium-dependent protein binding; protease binding; cytoskeletal protein binding; protein binding; calcium-dependent phospholipid binding; phosphatidylinositol-4,5-bisphosphate binding; cadherin binding involved in cell-cell adhesion; RNA binding; identical protein binding; bone sialoprotein binding; molecular function regulator; phosphatidylserine binding; calcium channel activity; virion binding; voltage-gated calcium channel activity involved in regulation of cytosolic calcium levels;
Cellular component	vesicle; cytosol; endosome; membrane; late endosome membrane; melanosome; ruffle; plasma membrane; lipid droplet; myelin sheath adaxonal region; Schmidt-Lanterman incisure; PCSK9-AnxA2 complex; macropinosome; basement membrane; cell surface; lysosomal membrane; basolateral plasma membrane; cell cortex; midbody; early endosome; perinuclear region of cytoplasm; sarcolemma; extrinsic component of plasma membrane; extracellular exosome; nucleus; extracellular space; azurophil granule lumen; cytoplasm; membrane raft; extracellular matrix; extracellular region; protein-containing complex; collagen-containing extracellular matrix;
Biological process	negative regulation of low-density lipoprotein particle receptor catabolic process; positive regulation of protein phosphorylation; protein heterotetramerization; fibrinolysis; body fluid secretion; collagen fibril organization; positive regulation of fibroblast proliferation; response to thyroid hormone; positive regulation of binding; positive regulation of vesicle fusion; membrane raft assembly; angiogenesis; vesicle budding from membrane; osteoclast development; cell-cell adhesion; negative regulation of catalytic activity; positive regulation of receptor recycling; neutrophil degranulation; positive regulation of low-density lipoprotein particle clearance; positive regulation of low-density lipoprotein particle receptor binding; positive regulation of low-density lipoprotein receptor activity; positive regulation of receptor-mediated endocytosis involved in cholesterol transport; negative regulation of formation of structure involved in a symbiotic process; positive regulation of vacuole organization; interleukin-12-mediated signaling pathway; protein localization to plasma membrane; growth plate cartilage development; regulation of plasminogen activation; biomineral tissue development; positive regulation of chondrocyte differentiation; positive regulation by host of viral process; regulation of cytosolic calcium ion concentration; positive regulation of calcium ion transport; endocardial cell differentiation; calcium ion transmembrane transport; positive regulation of viral life cycle;
	Sources:Amigo / QuickGO
Orthologs
	302
	12306
	ENSG00000182718
	ENSMUSG00000032231
	P07355
	P07356
	NM_001002857; NM_001002858; NM_001136015; NM_004039
	NM_007585
	NP_001002857; NP_001002858; NP_001129487; NP_004030
	NP_031611
	Wikidata
View/Edit Human	View/Edit Mouse

Annexin A2 also known as annexin II is a protein that in humans is encoded by the ANXA2 gene.

Annexin 2 is involved in diverse cellular processes such as cell motility (especially that of the epithelial cells), linkage of membrane-associated protein complexes to the actin cytoskeleton, endocytosis, fibrinolysis, ion channel formation, and cell matrix interactions. It is a calcium-dependent phospholipid-binding protein whose function is to help organize exocytosis of intracellular proteins to the extracellular domain. Annexin II is a pleiotropic protein meaning that its function is dependent on place and time in the body.