Annexin A3

ANXA3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1AII, 1AXN
Identifiers
Aliases	ANXA3, ANX3, annexin A3
External IDs	OMIM: 106490; MGI: 1201378; HomoloGene: 68445; GeneCards: ANXA3; OMA:ANXA3 - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	78,610,451 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	96,993,825 bp
RNA expression pattern
	Top expressed in
	right lung; ; germinal epithelium; ; bone marrow; ; upper lobe of left lung; ; bone marrow cells; ; minor salivary glands; ; left lobe of thyroid gland; ; trabecular bone; ; right lobe of thyroid gland; ; body of stomach;
	Top expressed in
	right lung lobe; ; mucous cell of stomach; ; pyloric antrum; ; endothelial cell of lymphatic vessel; ; left lung; ; granulocyte; ; left lung lobe; ; decidua; ; epithelium of stomach; ; gastrula;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	phospholipase inhibitor activity; calcium ion binding; phospholipase A2 inhibitor activity; calcium-dependent protein binding; calcium-dependent phospholipid binding;
Cellular component	cytoplasm; phagocytic vesicle membrane; membrane; plasma membrane; axon; soma; dendrite; specific granule; extracellular exosome; cytosol;
Biological process	negative regulation of catalytic activity; positive regulation of DNA metabolic process; neutrophil degranulation; positive regulation of DNA-binding transcription factor activity; response to glucocorticoid; positive regulation of angiogenesis; positive regulation of endothelial cell migration; defense response to bacterium; animal organ regeneration; phagocytosis; response to growth factor; hippocampus development; homophilic cell adhesion via plasma membrane adhesion molecules; regulation of NMDA receptor activity;
	Sources:Amigo / QuickGO
Orthologs
	306
	11745
	ENSG00000138772
	ENSMUSG00000029484
	P12429
	O35639
	NM_005139
	NM_013470
	NP_005130
	NP_038498
	Wikidata
View/Edit Human	View/Edit Mouse

Annexin A3 is a protein that in humans is encoded by the ANXA3 gene.

It is abnormally expressed in fetuses of both IVF and ICSI, which may contribute to the increase risk of birth defects in these ART.

This gene encodes a member of the annexin family. Members of this calcium-dependent phospholipid-binding protein family play a role in the regulation of cellular growth and in signal transduction pathways. This protein functions in the inhibition of phospholipase A2 and cleavage of inositol 1,2-cyclic phosphate to form inositol 1-phosphate. This protein may also play a role in anti-coagulation.