AP2B1

AP2B1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1E42, 2G30, 2IV8, 2IV9, 2JKR, 2JKT, 2VGL, 2XA7, 4UQI
Identifiers
Aliases	AP2B1, ADTB2, AP105B, AP2-BETA, CLAPB1, adaptor related protein complex 2 beta 1 subunit, adaptor related protein complex 2 subunit beta 1
External IDs	OMIM: 601025; MGI: 1919020; HomoloGene: 68176; GeneCards: AP2B1; OMA:AP2B1 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	35,726,413 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	83,295,861 bp
RNA expression pattern
	Top expressed in
	ganglionic eminence; ; ventricular zone; ; Brodmann area 10; ; islet of Langerhans; ; stromal cell of endometrium; ; rectum; ; right frontal lobe; ; cingulate gyrus; ; anterior cingulate cortex; ; C1 segment;
	Top expressed in
	spermatid; ; seminiferous tubule; ; spermatocyte; ; dentate gyrus of hippocampal formation granule cell; ; superior frontal gyrus; ; lateral septal nucleus; ; tail of embryo; ; cerebellar cortex; ; somite; ; subiculum;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	clathrin adaptor activity; protein-containing complex binding; clathrin binding; signal sequence binding; protein binding; cargo receptor activity;
Cellular component	endocytic vesicle membrane; cytosol; clathrin-coated endocytic vesicle membrane; membrane; clathrin coat; plasma membrane; trans-Golgi network; endolysosome membrane; membrane coat; clathrin-coated pit; clathrin adaptor complex; AP-2 adaptor complex; clathrin-coated endocytic vesicle; postsynapse; glutamatergic synapse;
Biological process	cardiac septum development; endocytosis; ventricular septum development; antigen processing and presentation of exogenous peptide antigen via MHC class II; ephrin receptor signaling pathway; mitigation of host defenses by virus; coronary vasculature development; aorta development; heart development; clathrin-dependent endocytosis; clathrin coat assembly; protein transport; intracellular protein transport; vesicle-mediated transport; microtubule-based movement; Wnt signaling pathway, planar cell polarity pathway; membrane organization; neurotransmitter receptor internalization; low-density lipoprotein particle receptor catabolic process; low-density lipoprotein particle clearance; transport; positive regulation of endocytosis; postsynaptic neurotransmitter receptor internalization; negative regulation of neuron death; positive regulation of protein localization to membrane;
	Sources:Amigo / QuickGO
Orthologs
	163
	71770
	ENSG00000006125
	ENSMUSG00000035152
	P63010
	Q9DBG3
	NM_001030006; NM_001282
	NM_001035854; NM_027915
	NP_001025177; NP_001273
	NP_001030931; NP_082191
	Wikidata
View/Edit Human	View/Edit Mouse

AP-2 complex subunit beta is a protein that in humans is encoded by the AP2B1 gene.