AP5M1

AP5M1
Identifiers
Aliases	AP5M1, C14orf108, MUDENG, Mu5, MuD, adaptor related protein complex 5 mu 1 subunit, adaptor related protein complex 5 subunit mu 1
External IDs	OMIM: 614368; MGI: 1921635; HomoloGene: 10081; GeneCards: AP5M1; OMA:AP5M1 - orthologs
Gene location (Human)
Chr.	Chromosome 14 (human)
End	57,298,742 bp
RNA expression pattern
	Top expressed in
	jejunal mucosa; ; Epithelium of choroid plexus; ; endothelial cell; ; mucosa of sigmoid colon; ; retinal pigment epithelium; ; palpebral conjunctiva; ; rectum; ; right ventricle; ; duodenum; ; kidney tubule;
	n/a
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding;
Cellular component	cytoplasm; lysosomal membrane; cytosol; endosome; late endosome; lysosome; AP-type membrane coat adaptor complex; membrane; late endosome membrane;
Biological process	protein transport; endosomal transport;
	Sources:Amigo / QuickGO
Orthologs
	55745
	74385
	ENSG00000053770
	n/a
	Q9H0R1
	Q8BJ63
	NM_018229
	NM_144535; NM_001360070
	NP_060699
	NP_653118; NP_001346999
	Wikidata
View/Edit Human	View/Edit Mouse

AP-5 complex subunit mu (AP5M1), otherwise known as MUDENG (MuD), is a protein that is encoded by the AP5M1 gene. The AP5M1 gene was originally discovered when screening for genes which helped to promote death in Fas-mediated apoptosis. It is a highly conserved gene.

MuD is the medium-sized subunit of the AP5 adaptor complex. MuD is expressed throughout the body and is located within both the mitochondria as well as the endoplasmic reticulum (ER) of cells.

MuD has been shown to have the ability to induce apoptosis; however, there is evidence that it plays an anti-apoptotic role in apoptosis mediated by tumor necrosis factor-related apoptosis-inducing ligand (TRAIL).