APBB2

APBB2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1WGU, 2ROZ, 2YSZ, 2YT0, 2YT1
Identifiers
Aliases	APBB2, FE65L, FE65L1, amyloid beta precursor protein binding family B member 2
External IDs	OMIM: 602710; MGI: 108405; HomoloGene: 32079; GeneCards: APBB2; OMA:APBB2 - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	41,216,714 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	66,776,127 bp
RNA expression pattern
	Top expressed in
	buccal mucosa cell; ; Achilles tendon; ; sural nerve; ; dorsal motor nucleus of vagus nerve; ; inferior olivary nucleus; ; tendon of biceps brachii; ; internal globus pallidus; ; ventricular zone; ; corpus callosum; ; tibia;
	Top expressed in
	genital tubercle; ; lateral geniculate nucleus; ; renal corpuscle; ; medial dorsal nucleus; ; pontine nuclei; ; ankle; ; triceps brachii muscle; ; deep cerebellar nuclei; ; lateral septal nucleus; ; medial geniculate nucleus;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	protein binding; transcription factor binding; amyloid-beta binding;
Cellular component	growth cone; membrane; cytoplasm; lamellipodium; synapse; nucleus;
Biological process	positive regulation of apoptotic process; intracellular signal transduction; negative regulation of cell growth; negative regulation of apoptotic process; extracellular matrix organization; axon guidance; neuron migration; regulation of transcription, DNA-templated;
	Sources:Amigo / QuickGO
Orthologs
	323
	11787
	ENSG00000163697
	ENSMUSG00000029207
	Q92870
	Q9DBR4
NM_001166050; NM_001166051; NM_001166052; NM_001166053; NM_001166054;
	NM_004307; NM_173075; NM_001330656; NM_001330658
NM_001201413; NM_001201414; NM_001201415; NM_001201416; NM_009686;
	NM_001310626
NP_001159522; NP_001159523; NP_001159524; NP_001159525; NP_001159526;
	NP_001317585; NP_001317587; NP_004298; NP_775098
NP_001188342; NP_001188343; NP_001188344; NP_001188345; NP_001297555;
	NP_033816
	Wikidata
View/Edit Human	View/Edit Mouse

Amyloid beta A4 precursor protein-binding family B member 2 is a protein that in humans is encoded by the APBB2 gene.

The protein encoded by this gene interacts with the cytoplasmic domains of amyloid beta (A4) precursor protein and amyloid beta (A4) precursor-like protein 2. This protein contains two phosphotyrosine binding (PTB) domains, which are thought to function in signal transduction.