APC internal ribosome entry site (IRES)

APC internal ribosome entry site (IRES)
Predicted secondary structure and sequence conservation of IRES_APC
Identifiers
SymbolIRES_APC
RfamRF00462
Other data
RNA typeCis-reg; IRES
Domain(s)Eukaryota
GOGO:0043022
SOSO:0000243
PDB structuresPDBe

The APC internal ribosome entry site (IRES) is an RNA element which is located in the coding sequence of the APC gene. APC is a tumour suppressor gene which is associated with the inherited disease adenomatous polyposis coli (APC). It is thought that IRES-mediated translation of APC is important for an apoptotic cascade.

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