APEH (gene)

APEH
Identifiers
Aliases	APEH, AARE, ACPH, APH, D3F15S2, D3S48E, DNF15S2, OPH, acylaminoacyl-peptide hydrolase
External IDs	OMIM: 102645; MGI: 88041; HomoloGene: 1240; GeneCards: APEH; OMA:APEH - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	49,683,971 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	107,971,805 bp
RNA expression pattern
	Top expressed in
	mucosa of transverse colon; ; anterior pituitary; ; muscle of thigh; ; right lobe of thyroid gland; ; left lobe of thyroid gland; ; right adrenal gland; ; right adrenal cortex; ; apex of heart; ; left adrenal gland; ; left adrenal cortex;
	Top expressed in
	fetal liver hematopoietic progenitor cell; ; right kidney; ; human kidney; ; epithelium of small intestine; ; interventricular septum; ; duodenum; ; jejunum; ; left lobe of liver; ; spleen; ; intestinal villus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	omega peptidase activity; serine-type peptidase activity; protein binding; hydrolase activity; serine-type endopeptidase activity; identical protein binding; RNA binding;
Cellular component	nuclear membrane; extracellular exosome; extracellular region; cytoplasm; cytosol; ficolin-1-rich granule lumen;
Biological process	translational termination; amyloid-beta metabolic process; proteolysis; neutrophil degranulation;
	Sources:Amigo / QuickGO
Orthologs
	327
	235606
	ENSG00000164062
	ENSMUSG00000032590
	P13798
	Q8R146
	NM_001640
	NM_146226
	NP_001631
	NP_666338
	Wikidata
View/Edit Human	View/Edit Mouse

Acylamino-acid-releasing enzyme is an enzyme that in humans is encoded by the APEH gene.

This gene encodes the enzyme acylpeptide hydrolase, which catalyzes the hydrolysis of the terminal acetylated amino acid preferentially from small acetylated peptides. The acetyl amino acid formed by this hydrolase is further processed to acetate and a free amino acid by an aminoacylase. This gene is located within the same region of chromosome 3 (3p21) as the aminoacylase gene, and deletions at this locus are also associated with a decrease in aminoacylase activity. The acylpeptide hydrolase is a homotetrameric protein of 300 kDa with each subunit consisting of 732 amino acid residues. It can play an important role in destroying oxidatively-damaged proteins in living cells. Deletions of this gene locus are found in various types of carcinomas, including small-cell lung carcinoma and renal cell carcinoma.