APIP

APIP
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4M6R
Identifiers
Aliases	APIP, APIP2, CGI29, MMRP19, hCGI-29, APAF1 interacting protein
External IDs	OMIM: 612491; MGI: 1926788; HomoloGene: 6277; GeneCards: APIP; OMA:APIP - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	34,916,379 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	102,922,989 bp
RNA expression pattern
	Top expressed in
	C1 segment; ; muscle of thigh; ; right adrenal gland; ; corpus callosum; ; right adrenal cortex; ; monocyte; ; skeletal muscle tissue; ; left adrenal gland; ; left adrenal cortex; ; gastrocnemius muscle;
	Top expressed in
	right ventricle; ; interventricular septum; ; zygote; ; cardiac muscle tissue of left ventricle; ; muscle of thigh; ; secondary oocyte; ; right kidney; ; digastric muscle; ; temporal muscle; ; brown adipose tissue;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; metal ion binding; lyase activity; identical protein binding; methylthioribulose 1-phosphate dehydratase activity; zinc ion binding;
Cellular component	cytoplasm; cytosol;
Biological process	methionine biosynthetic process; negative regulation of apoptotic process; cellular amino acid biosynthetic process; regulation of ERK1 and ERK2 cascade; apoptotic process; pyroptosis; protein homotetramerization; L-methionine salvage from methylthioadenosine; L-methionine salvage from S-adenosylmethionine;
	Sources:Amigo / QuickGO
Orthologs
	51074
	56369
	ENSG00000149089
	ENSMUSG00000010911
	Q96GX9
	Q9WVQ5
	NM_015957
	NM_019735; NM_001355473; NM_001355474
	NP_057041
	NP_062709; NP_001342402; NP_001342403
	Wikidata
View/Edit Human	View/Edit Mouse

APAF1-interacting protein is a protein that in humans is encoded by the APIP gene. It is an enzyme with Methylthioribulose 1-phosphate dehydratase activity which is involved in the methionine salvage pathway.

APIP deficiency is associated with cell death and cancer.