APOBEC3B

APOBEC3B
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	5CQD, 5CQH, 5CQI, 5CQK, 2NBQ
Identifiers
Aliases	APOBEC3B, A3B, APOBEC1L, ARCD3, ARP4, DJ742C19.2, PHRBNL, bK150C2.2, apolipoprotein B mRNA editing enzyme catalytic subunit 3B
External IDs	OMIM: 607110; MGI: 1933111; HomoloGene: 105420; GeneCards: APOBEC3B; OMA:APOBEC3B - orthologs
Gene location (Human)
Chr.	Chromosome 22 (human)
End	38,992,804 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	79,800,107 bp
RNA expression pattern
	Top expressed in
	gonad; ; mucosa of transverse colon; ; bone marrow; ; rectum; ; blood; ; bone marrow cells; ; islet of Langerhans; ; stromal cell of endometrium; ; duodenum; ; appendix;
	Top expressed in
	mesenteric lymph nodes; ; thymus; ; granulocyte; ; bone marrow; ; embryo; ; aortic valve; ; spleen; ; subcutaneous adipose tissue; ; epithelium of urethra; ; ascending aorta;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines; zinc ion binding; catalytic activity; hydrolase activity; metal ion binding; deoxycytidine deaminase activity; RNA binding; cytidine deaminase activity;
Cellular component	nucleus; cytoplasm;
Biological process	negative regulation of transposition; innate immune response; immune system process; defense response to virus; cytidine deamination; cytidine to uridine editing; DNA demethylation;
	Sources:Amigo / QuickGO
Orthologs
	9582
	80287
	ENSG00000179750
	ENSMUSG00000009585
	Q9UH17
	Q99J72
	NM_004900; NM_001270411
	NM_001160415; NM_030255; NM_001347041
	NP_001257340; NP_004891
	NP_001153887; NP_001333970; NP_084531
	Wikidata
View/Edit Human	View/Edit Mouse

Probable DNA dC->dU-editing enzyme APOBEC-3B is a protein that in humans is encoded by the APOBEC3B gene.

This gene is a member of the cytidine deaminase gene family. It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1. It is thought that the proteins may be RNA editing enzymes and have roles in growth or cell cycle control. This gene along with APOBEC3A have been in recent years found associated with mutagenesis of several cancers. The APOBEC3A and APOBEC3B proteins can cause specific mutations in cancer genomes called APOBEC mutagenesis and several factors including genetic and environmental influence this mutation pattern among patients specifically in bladder and breast cancer. This gene is also overexpressed in multiple myeloma, possibly aiding its formation.