APOBEC3C

APOBEC3C
Available structures
PDB	Human UniProt search: PDBe RCSB
List of PDB id codes
	3VM8, 3VOW
Identifiers
Aliases	APOBEC3C, A3C, APOBEC1L, ARDC2, ARDC4, ARP5, PBI, bK150C2.3, apolipoprotein B mRNA editing enzyme catalytic subunit 3C
External IDs	OMIM: 607750; HomoloGene: 129856; GeneCards: APOBEC3C; OMA:APOBEC3C - orthologs
Gene location (Human)
Chr.	Chromosome 22 (human)
End	39,020,352 bp
RNA expression pattern
	Top expressed in
	white blood cell; ; granulocyte; ; monocyte; ; lymph node; ; right adrenal cortex; ; left adrenal gland; ; left adrenal cortex; ; rectum; ; stromal cell of endometrium; ; smooth muscle tissue;
	n/a
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding; hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines; catalytic activity; zinc ion binding; hydrolase activity; metal ion binding; RNA binding; cytidine deaminase activity;
Cellular component	nucleus; cytoplasm; P-body;
Biological process	negative regulation of viral genome replication; immune system process; defense response to virus; cytidine deamination; innate immune response; viral process; negative regulation of transposition; DNA demethylation; cytidine to uridine editing; negative regulation of single stranded viral RNA replication via double stranded DNA intermediate; DNA cytosine deamination;
	Sources:Amigo / QuickGO
Orthologs
	27350
	n/a
	ENSG00000244509
	n/a
	Q9NRW3
	n/a
	NM_014508
	n/a
	NP_055323
	n/a
	Wikidata
View/Edit Human

DNA dC->dU-editing enzyme APOBEC-3C is a protein that in humans is encoded by the APOBEC3C gene.

A3C belong to the A3 family of cytidine deaminases that act as restriction factors against diverse retroviruses. A3C was reported to inhibit simian immunodeficiency deficiency virus potently rather than HIV-1, in absence of viral infectivity factor, Vif. Enhancing A3C's catalytic activity had only a marginal effect on HIV-1 replication (in absence of Vif), the counteractive viral mechanism is unclear. A3C was also shown to inhibit other viruses.