APOBEC3F

APOBEC3F
Available structures
PDB	Human UniProt search: PDBe RCSB
List of PDB id codes
	3WUS, 4IOU, 4J4J, 5HX5, 5HX4
Identifiers
Aliases	APOBEC3F, A3F, ARP8, BK150C2.4.MRNA, KA6, apolipoprotein B mRNA editing enzyme catalytic subunit 3F
External IDs	OMIM: 608993; HomoloGene: 105867; GeneCards: APOBEC3F; OMA:APOBEC3F - orthologs
Gene location (Human)
Chr.	Chromosome 22 (human)
End	39,055,972 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; monocyte; ; spleen; ; right ovary; ; left ovary; ; right uterine tube; ; lymph node; ; right adrenal gland; ; left adrenal cortex; ; right adrenal cortex;
	n/a
	More reference expression data
	n/a
Gene ontology
Molecular function	cytidine deaminase activity; zinc ion binding; metal ion binding; hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines; protein binding; catalytic activity; RNA binding; hydrolase activity; identical protein binding;
Cellular component	cytoplasm; P-body; apolipoprotein B mRNA editing enzyme complex; nucleus; ribonucleoprotein complex;
Biological process	negative regulation of transposition; negative regulation of viral process; immune system process; base conversion or substitution editing; negative regulation of viral genome replication; defense response to virus; DNA cytosine deamination; DNA demethylation; innate immune response; negative regulation of single stranded viral RNA replication via double stranded DNA intermediate; positive regulation of defense response to virus by host; cytidine deamination; cytidine to uridine editing;
	Sources:Amigo / QuickGO
Orthologs
	200316
	n/a
	ENSG00000128394
	n/a
	Q8IUX4
	n/a
	NM_001006666; NM_145298
	n/a
	NP_001006667; NP_660341
	n/a
	Wikidata
View/Edit Human

DNA dC->dU-editing enzyme APOBEC-3F is a protein that in humans is encoded by the APOBEC3F gene.

This gene is a member of the cytidine deaminase gene family. It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1. It is thought that the proteins may be RNA editing enzymes and have roles in growth or cell cycle control. Alternatively spliced transcript variants encoding different isoforms have been identified.