APOL3

APOL3
Identifiers
Aliases	APOL3, APOLIII, CG121, CG12_1, apoL-III, apolipoprotein L3
External IDs	OMIM: 607253; HomoloGene: 129701; GeneCards: APOL3; OMA:APOL3 - orthologs
Gene location (Human)
Chr.	Chromosome 22 (human)
End	36,166,177 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; monocyte; ; apex of heart; ; gastric mucosa; ; pericardium; ; lymph node; ; spleen; ; subcutaneous adipose tissue; ; right lung; ; tendon of biceps brachii;
	n/a
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	signal transducer activity; lipid binding; lipid transporter activity;
Cellular component	cytoplasm; extracellular region; membrane;
Biological process	lipoprotein metabolic process; positive regulation of I-kappaB kinase/NF-kappaB signaling; lipid transport; inflammatory response; signal transduction; transport;
	Sources:Amigo / QuickGO
Orthologs
	80833
	n/a
	ENSG00000128284
	n/a
	O95236
	n/a
NM_014349; NM_030644; NM_145639; NM_145640; NM_145641;
	NM_145642
	n/a
NP_055164; NP_085147; NP_663614; NP_663615; NP_663616;
	NP_663617
	n/a
	Wikidata
View/Edit Human

Apolipoprotein L3 is a protein that in humans is encoded by the APOL3 gene. Expressed in the gut, it has antibiotic properties.

This gene is a member of the apolipoprotein L gene family. The encoded protein is found in the cytoplasm, where it may affect the movement of lipids or allow the binding of lipids to organelles. In addition, expression of this gene is upregulated by tumor necrosis factor-alpha in endothelial cells lining the normal and atherosclerotic iliac artery and aorta. Six transcript variants encoding three different isoforms have been found for this gene.