APPBP2

APPBP2
Identifiers
Aliases	APPBP2, APP-BP2, HS.84084, PAT1, amyloid beta precursor protein binding protein 2
External IDs	OMIM: 605324; MGI: 1914134; HomoloGene: 31378; GeneCards: APPBP2; OMA:APPBP2 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	60,526,242 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	85,125,956 bp
RNA expression pattern
	Top expressed in
	endothelial cell; ; Brodmann area 23; ; lateral nuclear group of thalamus; ; cerebellar vermis; ; pars compacta; ; pars reticulata; ; buccal mucosa cell; ; dorsal motor nucleus of vagus nerve; ; external globus pallidus; ; internal globus pallidus;
	Top expressed in
	Rostral migratory stream; ; vas deferens; ; Gonadal ridge; ; abdominal wall; ; umbilical cord; ; efferent ductule; ; epithelium of lens; ; migratory enteric neural crest cell; ; ventromedial nucleus; ; ventral tegmental area;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	microtubule motor activity; protein binding;
Cellular component	microtubule; cytoskeleton; cytoplasmic vesicle membrane; membrane; nucleus; microtubule associated complex; cytoplasm;
Biological process	protein transport; intracellular transport; intracellular protein transport;
	Sources:Amigo / QuickGO
Orthologs
	10513
	66884
	ENSG00000062725
	ENSMUSG00000018481
	Q92624
	Q9DAX9
	NM_001282476; NM_006380
	NM_025825
	NP_001269405; NP_006371
	NP_080101
	Wikidata
View/Edit Human	View/Edit Mouse

Amyloid protein-binding protein 2 is a protein that in humans is encoded by the APPBP2 gene.

The protein encoded by this gene interacts with microtubules and is functionally associated with beta-amyloid precursor protein transport and/or processing. The beta-amyloid precursor protein is a cell surface protein with signal-transducing properties, and it is thought to play a role in the pathogenesis of Alzheimer's disease. This gene has been found to be highly expressed in breast cancer. Multiple polyadenylation sites have been found for this gene.