Aquaporin-5

AQP5
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3D9S, 5C5X, 5DYE
Identifiers
Aliases	AQP5, AQP-5, PPKB, aquaporin 5
External IDs	OMIM: 600442; MGI: 106215; HomoloGene: 20398; GeneCards: AQP5; OMA:AQP5 - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	49,965,682 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	99,492,710 bp
RNA expression pattern
	Top expressed in
	olfactory zone of nasal mucosa; ; palpebral conjunctiva; ; left testis; ; right testis; ; parotid gland; ; skin of leg; ; nasal epithelium; ; minor salivary glands; ; trachea; ; skin of abdomen;
	Top expressed in
	submandibular gland; ; parotid gland; ; lacrimal gland; ; right lung; ; right lung lobe; ; respiratory epithelium; ; olfactory epithelium; ; trachea; ; epithelium of lens; ; left lung;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transporter activity; protein binding; water channel activity; identical protein binding; channel activity;
Cellular component	integral component of membrane; membrane; plasma membrane; integral component of plasma membrane; microvillus; basal plasma membrane; apical plasma membrane; endoplasmic reticulum; extracellular exosome; cytoplasmic vesicle membrane; cytoplasmic vesicle;
Biological process	excretion; water transport; pancreatic juice secretion; saliva secretion; odontogenesis; ion transmembrane transport; camera-type eye morphogenesis; carbon dioxide transport; transport; transmembrane transport; protein homotetramerization; cellular hypotonic response;
	Sources:Amigo / QuickGO
Orthologs
	362
	11830
	ENSG00000161798
	ENSMUSG00000044217
	P55064
	Q9WTY4
	NM_001651
	NM_009701
	NP_001642
	NP_033831
	Wikidata
View/Edit Human	View/Edit Mouse

Aquaporin-5 (AQP-5) is a protein that in humans is encoded by the AQP5 gene.

Aquaporin-5 (AQP-5) is a water channel protein. Aquaporins are a family of small integral membrane proteins related to the major intrinsic protein (MIP or AQP0). Aquaporin-5 plays a role in the generation of saliva, tears and pulmonary secretions. AQP0, AQP2, AQP5, and AQP6 are closely related and all map to 12q13.

AQP-5 features a homotetrameric structure embedded in the cell membrane with the center of each monomer acting as a water pore. Each monomer structure is a transmembrane protein which have an asparagine–proline–alanine (NPA) hydrophobic residue embedded in the membrane of the cell. The NPA residue plays a role in water and solute permeability across the membrane of the cell.