Aquaporin-7

AQP7
Identifiers
Aliases	AQP7, AQP7L, AQP9, AQPap, GLYCQTL, aquaporin 7
External IDs	OMIM: 602974; MGI: 1314647; HomoloGene: 48000; GeneCards: AQP7; OMA:AQP7 - orthologs
Gene location (Human)
Chr.	Chromosome 9 (human)
End	33,402,682 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	41,048,139 bp
RNA expression pattern
	Top expressed in
	apex of heart; ; subcutaneous adipose tissue; ; left ventricle; ; sural nerve; ; right auricle of heart; ; muscle of thigh; ; lactiferous gland; ; gastric mucosa; ; duodenum; ; quadriceps femoris muscle;
	Top expressed in
	spermatid; ; seminiferous tubule; ; brown adipose tissue; ; aortic valve; ; white adipose tissue; ; proximal tubule; ; right kidney; ; tunica adventitia of aorta; ; ascending aorta; ; muscle of thigh;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	glycerol channel activity; water channel activity; channel activity; urea transmembrane transporter activity;
Cellular component	cytoplasm; integral component of membrane; plasma membrane; integral component of plasma membrane; membrane; cell-cell junction; lipid droplet; cell cortex; cytoplasmic vesicle membrane; cytoplasmic vesicle;
Biological process	water transport; excretion; glycerol transport; generation of precursor metabolites and energy; transmembrane transport; urea transmembrane transport;
	Sources:Amigo / QuickGO
Orthologs
	364
	11832
	ENSG00000165269
	ENSMUSG00000028427
	O14520
	O54794
NM_001170; NM_001318156; NM_001318157; NM_001318158; NM_001376191;
	NM_001376192; NM_001376193
	NM_007473
NP_001161; NP_001305085; NP_001305086; NP_001305087; NP_001363120;
	NP_001363121; NP_001363122
NP_031499; NP_001365567; NP_001365568; NP_001365569; NP_001365570;
	NP_001365571
	Wikidata
View/Edit Human	View/Edit Mouse

Aquaporin-7 (AQP-7) is a protein that in humans is encoded by the AQP7 gene.

Aquaporins/major intrinsic proteins (MIP) are a family of water-selective membrane channels. Aquaporin-7 has greater sequence similarity with AQP3 and AQP9 and they may be a subfamily. Aquaporin-7 and AQP3 are at the same chromosomal location suggesting that 9p13 may be a site of an aquaporin cluster. Aquaporin-7 facilitates water, glycerol and urea transport. It may play an important role in thermoregulation in the form of perspiration, and sperm function.