Aquaporin-9

AQP9
Identifiers
Aliases	AQP9, AQP-9, HsT17287, SSC1, T17287, aquaporin 9
External IDs	OMIM: 602914; MGI: 1891066; HomoloGene: 41405; GeneCards: AQP9; OMA:AQP9 - orthologs
Gene location (Human)
Chr.	Chromosome 15 (human)
End	58,185,911 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	71,075,964 bp
RNA expression pattern
	Top expressed in
	blood; ; monocyte; ; right lobe of liver; ; periodontal fiber; ; granulocyte; ; caput epididymis; ; germinal epithelium; ; corpus epididymis; ; bone marrow; ; right lung;
	Top expressed in
	left lobe of liver; ; spermatocyte; ; granulocyte; ; spermatid; ; zygote; ; secondary oocyte; ; seminiferous tubule; ; primary oocyte; ; blood; ; blastocyst;
	More reference expression data
	n/a
Gene ontology
Molecular function	porin activity; carboxylic acid transmembrane transporter activity; polyol transmembrane transporter activity; water transmembrane transporter activity; purine nucleobase transmembrane transporter activity; pyrimidine nucleobase transmembrane transporter activity; amine transmembrane transporter activity; water channel activity; urea channel activity; glycerol channel activity; channel activity; urea transmembrane transporter activity;
Cellular component	integral component of membrane; intracellular membrane-bounded organelle; membrane; plasma membrane; integral component of plasma membrane; basolateral plasma membrane;
Biological process	canalicular bile acid transport; excretion; water transport; amine transport; response to organic substance; water homeostasis; response to osmotic stress; polyol transport; carboxylic acid transport; immune response; pyrimidine nucleobase transport; response to mercury ion; glycerol transport; cellular response to cAMP; purine nucleobase transport; carboxylic acid transmembrane transport; purine nucleobase transmembrane transport; pyrimidine-containing compound transmembrane transport; transmembrane transport; urea transmembrane transport;
	Sources:Amigo / QuickGO
Orthologs
	366
	64008
	ENSG00000103569
	ENSMUSG00000032204
	O43315
	Q9JJJ3
	NM_020980; NM_001320635; NM_001320636
	NM_001271843; NM_022026
	NP_001307564; NP_001307565; NP_066190
	NP_001258772; NP_071309
	Wikidata
View/Edit Human	View/Edit Mouse

Aquaporin-9 (AQP-9) is a protein that in humans is encoded by the AQP9 gene.

The aquaporins/major intrinsic protein are a family of water-selective membrane channels. Aquaporin-9 has greater sequence similarity with AQP3 and AQP7 and they may be a subfamily. Aquaporin-9 allows passage of a wide variety of noncharged solutes. AQP-9 stimulates urea transport and osmotic water permeability; there are contradicting reports about its role in providing glycerol permeability. Aquaporin-9 may also have some role in specialized leukocyte functions such as immunological response and bactericidal activity.