Amphiregulin

AREG
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2RNL
Identifiers
Aliases	AREG, AR, AREGB, CRDGF, SDGF, amphiregulin
External IDs	OMIM: 104640; MGI: 88068; HomoloGene: 1252; GeneCards: AREG; OMA:AREG - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	74,455,005 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	91,296,291 bp
RNA expression pattern
	Top expressed in
	mucosa of urinary bladder; ; right lung; ; glutes; ; gallbladder; ; mucosa of paranasal sinus; ; amniotic fluid; ; placenta; ; upper lobe of left lung; ; rectum; ; left uterine tube;
	Top expressed in
	mucous cell of stomach; ; pyloric antrum; ; duodenum; ; lactiferous gland; ; large intestine; ; colon; ; left colon; ; embryo; ; embryo; ; lip;
	More reference expression data
	n/a
Gene ontology
Molecular function	cytokine activity; epidermal growth factor receptor binding; protein binding; growth factor activity;
Cellular component	cytoplasm; integral component of membrane; endoplasmic reticulum membrane; membrane; intracellular anatomical structure; cell surface; ER to Golgi transport vesicle membrane; endoplasmic reticulum-Golgi intermediate compartment membrane; nucleus; Golgi membrane; extracellular space; extracellular region; clathrin-coated vesicle membrane;
Biological process	dichotomous subdivision of terminal units involved in mammary gland duct morphogenesis; G protein-coupled receptor signaling pathway; response to estradiol; epidermal growth factor receptor signaling pathway; response to organic cyclic compound; cell-cell signaling; mammary gland branching involved in thelarche; response to peptide hormone; response to glucocorticoid; mammary gland alveolus development; negative regulation of osteoblast differentiation; endoplasmic reticulum to Golgi vesicle-mediated transport; epithelial cell proliferation involved in mammary gland duct elongation; COPII vesicle coating; glial cell proliferation; response to cAMP; positive regulation of phosphorylation; cell population proliferation; neuron projection development; response to hydrogen peroxide; positive regulation of peptidyl-tyrosine phosphorylation; regulation of signaling receptor activity; positive regulation of cell population proliferation; MAPK cascade; signal transduction; negative regulation of epidermal growth factor receptor signaling pathway; positive regulation of protein kinase B signaling; membrane organization; positive regulation of keratinocyte proliferation;
	Sources:Amigo / QuickGO
Orthologs
	374
	11839
	ENSG00000109321
	ENSMUSG00000029378
	P15514
	P31955
	NM_001657
	NM_009704
	NP_001648
	NP_033834
	Wikidata
View/Edit Human	View/Edit Mouse

Amphiregulin, also known as AREG, is a protein synthesized as a transmembrane glycoprotein with 252 aminoacids and it is encoded by the AREG gene. in humans.