ARF6

ARF6
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1E0S, 2A5D, 2A5F, 2A5G, 2BAO, 2BAU, 2J5X, 2W83, 3LVQ, 3LVR, 4FME, 3N5C, 3PCR, 4KAX
Identifiers
Aliases	ARF6, ADP-ribosylation factor 6, ADP ribosylation factor 6
External IDs	OMIM: 600464; MGI: 99435; HomoloGene: 1256; GeneCards: ARF6; OMA:ARF6 - orthologs
Gene location (Human)
Chr.	Chromosome 14 (human)
End	49,897,054 bp
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	69,420,557 bp
RNA expression pattern
	Top expressed in
	gingival epithelium; ; oral cavity; ; amniotic fluid; ; buccal mucosa cell; ; human penis; ; vulva; ; germinal epithelium; ; trabecular bone; ; mucosa of sigmoid colon; ; parietal pleura;
	Top expressed in
	conjunctival fornix; ; cumulus cell; ; hair follicle; ; Paneth cell; ; condyle; ; endocardial cushion; ; endothelial cell of lymphatic vessel; ; seminal vesicula; ; semi-lunar valve; ; motor neuron;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; protein N-terminus binding; GTP binding; protein binding; GTPase activity; thioesterase binding;
Cellular component	cytoplasm; recycling endosome; endosome; Golgi apparatus; cell projection; membrane; focal adhesion; ruffle; myelin sheath; plasma membrane; endocytic vesicle; intracellular anatomical structure; cell cortex; early endosome; endosome membrane; extracellular exosome; filopodium membrane; recycling endosome membrane; cleavage furrow; cytosol; Flemming body; early endosome membrane; presynapse; glutamatergic synapse;
Biological process	establishment of epithelial cell polarity; cell differentiation; regulation of filopodium assembly; positive regulation of actin filament polymerization; ruffle organization; small GTPase mediated signal transduction; regulation of Rac protein signal transduction; nervous system development; negative regulation of dendrite development; cell division; negative regulation of receptor-mediated endocytosis; cell adhesion; protein localization to cell surface; protein transport; protein localization to endosome; cell cycle; liver development; myeloid cell apoptotic process; cortical actin cytoskeleton organization; vesicle-mediated transport; regulation of dendritic spine development; hepatocyte apoptotic process; transport; positive regulation of protein localization to plasma membrane; intracellular protein transport; regulation of neuron projection development; endocytic recycling; synaptic vesicle endocytosis; positive regulation of keratinocyte migration; ruffle assembly; maintenance of postsynaptic density structure; positive regulation of adherens junction organization; regulation of presynapse assembly; cellular response to nerve growth factor stimulus; negative regulation of protein localization to cell surface; positive regulation of protein secretion; positive regulation of protein homodimerization activity;
	Sources:Amigo / QuickGO
Orthologs
	382
	11845
	ENSG00000165527
	ENSMUSG00000044147
	P62330
	P62331
	NM_001663
	NM_007481
	NP_001654
	NP_031507
	Wikidata
View/Edit Human	View/Edit Mouse

ADP-ribosylation factor 6 (ARF6) is a member of the ADP ribosylation factor family of GTP-binding proteins. ARF6 has a variety of cellular functions that are frequently involved in trafficking of biological membranes and transmembrane protein cargo. ARF6 has specifically been implicated in endocytosis of plasma membrane proteins and also, to a lesser extent, plasma membrane protein recycling.