ARFGEF1

ARFGEF1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3LTL, 5EE5
Identifiers
Aliases	ARFGEF1, ARFGEP1, BIG1, P200, ADP ribosylation factor guanine nucleotide exchange factor 1
External IDs	OMIM: 604141; MGI: 2442988; HomoloGene: 4687; GeneCards: ARFGEF1; OMA:ARFGEF1 - orthologs
Gene location (Human)
Chr.	Chromosome 8 (human)
End	67,343,781 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	10,302,895 bp
RNA expression pattern
	Top expressed in
	gonad; ; secondary oocyte; ; epithelium of nasopharynx; ; sural nerve; ; bronchial epithelial cell; ; testicle; ; mucosa of sigmoid colon; ; jejunal mucosa; ; bone marrow; ; tibia;
	Top expressed in
	gastrula; ; crypt of lieberkuhn of small intestine; ; submandibular gland; ; transitional epithelium of urinary bladder; ; cumulus cell; ; zygote; ; knee joint; ; triceps brachii muscle; ; cardiac muscle tissue of left ventricle; ; plantaris muscle;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	GTPase activator activity; guanyl-nucleotide exchange factor activity; myosin binding; protein binding; protein kinase A regulatory subunit binding;
Cellular component	cytosol; Golgi apparatus; membrane; nuclear matrix; Golgi membrane; nucleoplasm; trans-Golgi network; nucleolus; small nuclear ribonucleoprotein complex; perinuclear region of cytoplasm; nucleus; cytoplasm;
Biological process	endomembrane system organization; positive regulation of protein kinase B signaling; negative regulation of actin filament polymerization; Golgi organization; positive regulation of wound healing; regulation of ARF protein signal transduction; negative regulation of GTPase activity; protein transport; neuron projection development; regulation of establishment of cell polarity; exocytosis; positive regulation of GTPase activity; vesicle-mediated transport;
	Sources:Amigo / QuickGO
Orthologs
	10565
	211673
	ENSG00000066777
	ENSMUSG00000067851
	Q9Y6D6
	G3X9K3
	NM_006421
	NM_001102430
	NP_006412
	NP_001095900
	Wikidata
View/Edit Human	View/Edit Mouse

Brefeldin A-inhibited guanine nucleotide-exchange protein 1 is a protein that in humans is encoded by the ARFGEF1 gene.