ARHGEF10

ARHGEF10
Identifiers
Aliases	ARHGEF10, GEF10, SNCV, Rho guanine nucleotide exchange factor 10
External IDs	OMIM: 608136; MGI: 2444453; HomoloGene: 22827; GeneCards: ARHGEF10; OMA:ARHGEF10 - orthologs
Gene location (Human)
Chr.	Chromosome 8 (human)
End	1,958,641 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	15,001,085 bp
RNA expression pattern
	Top expressed in
	sural nerve; ; right lung; ; corpus callosum; ; apex of heart; ; C1 segment; ; upper lobe of left lung; ; ascending aorta; ; gastric mucosa; ; right testis; ; Descending thoracic aorta;
	Top expressed in
	sciatic nerve; ; submandibular gland; ; deep cerebellar nuclei; ; ascending aorta; ; globus pallidus; ; lumbar subsegment of spinal cord; ; genital tubercle; ; aortic valve; ; molar; ; optic nerve;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; kinesin binding; guanyl-nucleotide exchange factor activity;
Cellular component	cytosol; centrosome;
Biological process	mitotic spindle assembly; regulation of Rho protein signal transduction; positive regulation of stress fiber assembly; myelination in peripheral nervous system; centrosome duplication; activation of GTPase activity; actin cytoskeleton organization;
	Sources:Amigo / QuickGO
Orthologs
	9639
	234094
	ENSG00000104728; ENSG00000274726
	ENSMUSG00000071176
	O15013
	Q8C033
	NM_001308152; NM_001308153; NM_014629
	NM_001037736; NM_172751
	NP_001295081; NP_001295082; NP_055444
	NP_001032825; NP_766339
	Wikidata
View/Edit Human	View/Edit Mouse

The human ARHGEF10 gene encodes the protein Rho guanine nucleotide exchange factor 10.

Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals.