ARHGEF11

ARHGEF11
Available structures
PDB	Human UniProt search: PDBe RCSB
List of PDB id codes
	1HTJ, 1XCG, 2DLS, 3KZ1, 3T06, 5E6P
Identifiers
Aliases	ARHGEF11, GTRAP48, PDZ-RHOGEF, Rho guanine nucleotide exchange factor 11
External IDs	OMIM: 605708; MGI: 2441869; HomoloGene: 11409; GeneCards: ARHGEF11; OMA:ARHGEF11 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	157,045,742 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	87,645,341 bp
RNA expression pattern
	Top expressed in
	right testis; ; left testis; ; right hemisphere of cerebellum; ; blood; ; monocyte; ; right frontal lobe; ; superior frontal gyrus; ; primary visual cortex; ; sural nerve; ; prefrontal cortex;
	Top expressed in
	zygote; ; genital tubercle; ; tail of embryo; ; primary oocyte; ; hand; ; secondary oocyte; ; granulocyte; ; dentate gyrus of hippocampal formation granule cell; ; otolith organ; ; cerebellar cortex;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	GTPase activator activity; protein binding; guanyl-nucleotide exchange factor activity; G protein-coupled receptor binding;
Cellular component	cytoplasm; cytosol; membrane;
Biological process	G protein-coupled receptor signaling pathway; positive regulation of transcription, DNA-templated; regulation of cell growth; Rho protein signal transduction; establishment of cell polarity; positive regulation of apoptotic process; regulation of Rho protein signal transduction; regulation of small GTPase mediated signal transduction; striated muscle contraction; actin cytoskeleton organization; positive regulation of GTPase activity;
	Sources:Amigo / QuickGO
Orthologs
	9826
	213498
	ENSG00000132694
	ENSMUSG00000041977
	O15085
	n/a
	NM_014784; NM_198236; NM_001377418; NM_001377419
	NM_001003912; NM_001360195; NM_001360197
	NP_055599; NP_937879; NP_001364347; NP_001364348
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Rho guanine nucleotide exchange factor 11 is a protein that in humans is encoded by the ARHGEF11 gene. This protein is also called RhoGEF11 or PDZ-RhoGEF.