ARHGEF12

ARHGEF12
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1TXD, 1X86, 2OMJ, 2OS6
Identifiers
Aliases	ARHGEF12, LARG, PRO2792, Rho guanine nucleotide exchange factor 12
External IDs	OMIM: 604763; MGI: 1916882; HomoloGene: 9088; GeneCards: ARHGEF12; OMA:ARHGEF12 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	120,489,937 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	43,018,534 bp
RNA expression pattern
	Top expressed in
	skin of thigh; ; visceral pleura; ; right ventricle; ; renal medulla; ; mucosa of paranasal sinus; ; parietal pleura; ; skin of hip; ; myocardium; ; human penis; ; retinal pigment epithelium;
	Top expressed in
	vestibular membrane of cochlear duct; ; left lung lobe; ; ciliary body; ; retinal pigment epithelium; ; substantia nigra; ; Epithelium of choroid plexus; ; median eminence; ; iris; ; superior colliculus; ; right lung;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	protein binding; G protein-coupled receptor binding; GTPase activator activity; guanyl-nucleotide exchange factor activity;
Cellular component	cytoplasm; cytosol; extracellular exosome; membrane;
Biological process	positive regulation of GTPase activity; regulation of Rho protein signal transduction; intracellular signal transduction; regulation of small GTPase mediated signal transduction; positive regulation of apoptotic process; G protein-coupled receptor signaling pathway; regulation of molecular function; Rho protein signal transduction;
	Sources:Amigo / QuickGO
Orthologs
	23365
	69632
	ENSG00000196914
	ENSMUSG00000059495
	Q9NZN5
	Q8R4H2
	NM_001198665; NM_001301084; NM_015313
	NM_027144; NM_001359232
	NP_001185594; NP_001288013; NP_056128
	NP_081420; NP_001346161
	Wikidata
View/Edit Human	View/Edit Mouse

Rho guanine nucleotide exchange factor 12 is a protein that in humans is encoded by the ARHGEF12 gene. This protein is also called RhoGEF12 or Leukemia-associated Rho guanine nucleotide exchange factor (LARG).