ARHGEF5

ARHGEF5
Identifiers
Aliases	ARHGEF5, GEF5, P60, TIM, TIM1, Rho guanine nucleotide exchange factor 5
External IDs	OMIM: 600888; MGI: 1858952; HomoloGene: 66300; GeneCards: ARHGEF5; OMA:ARHGEF5 - orthologs
Gene location (Human)
Chr.	Chromosome 7 (human)
End	144,380,632 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	43,266,254 bp
RNA expression pattern
	Top expressed in
	skin of leg; ; skin of abdomen; ; mucosa of transverse colon; ; left lobe of thyroid gland; ; right lobe of thyroid gland; ; duodenum; ; minor salivary glands; ; human kidney; ; body of pancreas; ; prostate;
	Top expressed in
	skin of external ear; ; epithelium of stomach; ; duodenum; ; lip; ; jejunum; ; large intestine; ; colon; ; pyloric antrum; ; mucous cell of stomach; ; left colon;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	GTP binding; protein binding; lipid binding; guanyl-nucleotide exchange factor activity;
Cellular component	cytoplasm; cell projection; plasma membrane; nucleoplasm; cell junction; podosome; nucleus; cell periphery; cytosol;
Biological process	intracellular signal transduction; regulation of actin cytoskeleton organization; positive regulation of JUN kinase activity; regulation of GTPase activity; positive regulation of DNA-binding transcription factor activity; positive regulation of podosome assembly; myeloid dendritic cell chemotaxis; positive regulation of GTPase activity; positive regulation of protein import; regulation of ERK1 and ERK2 cascade; regulation of Rho protein signal transduction; regulation of cytoskeleton organization; actin cytoskeleton organization; positive regulation of stress fiber assembly; positive regulation of apoptotic process; regulation of small GTPase mediated signal transduction; G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	7984
	54324
	ENSG00000050327
	ENSMUSG00000033542
	Q12774
	E9Q7D5
	NM_001002861; NM_005435
	NM_133674
	NP_005426
	NP_598435
	Wikidata
View/Edit Human	View/Edit Mouse

Rho guanine nucleotide exchange factor 5 is a protein that in humans is encoded by the ARHGEF5 gene.

Rho GTPases play a fundamental role in numerous cellular processes initiated by extracellular stimuli that work through G protein-coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. This protein may be involved in the control of cytoskeletal organization.