ARNT2

ARNT2
Identifiers
Aliases	ARNT2, WEDAS, bHLHe1, aryl hydrocarbon receptor nuclear translocator 2
External IDs	OMIM: 606036; MGI: 107188; HomoloGene: 7230; GeneCards: ARNT2; OMA:ARNT2 - orthologs
Gene location (Human)
Chr.	Chromosome 15 (human)
End	80,597,933 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	84,059,384 bp
RNA expression pattern
	Top expressed in
	external globus pallidus; ; middle temporal gyrus; ; frontal pole; ; middle frontal gyrus; ; Brodmann area 10; ; entorhinal cortex; ; optic nerve; ; superior vestibular nucleus; ; parietal lobe; ; ventral tegmental area;
	Top expressed in
	subiculum; ; superior frontal gyrus; ; paraventricular nucleus of hypothalamus; ; globus pallidus; ; nucleus accumbens; ; dorsal tegmental nucleus; ; dorsomedial hypothalamic nucleus; ; ganglionic eminence; ; ventral tegmental area; ; dentate gyrus of hippocampal formation granule cell;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA binding; protein dimerization activity; DNA-binding transcription factor activity; aryl hydrocarbon receptor binding; DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding; protein binding; protein heterodimerization activity; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	cytoplasm; transcription regulator complex; nucleus; nucleoplasm;
Biological process	response to estradiol; response to hypoxia; regulation of transcription, DNA-templated; negative regulation of apoptotic process; in utero embryonic development; transcription by RNA polymerase II; transcription, DNA-templated; positive regulation of transcription, DNA-templated; central nervous system development; brain development; positive regulation of cell population proliferation; xenobiotic metabolic process; positive regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	9915
	11864
	ENSG00000172379
	ENSMUSG00000015709
	Q9HBZ2
	Q61324
	NM_014862
	NM_007488
	NP_055677; NP_055677.3
	NP_031514
	Wikidata
View/Edit Human	View/Edit Mouse

Aryl hydrocarbon receptor nuclear translocator 2 is a protein that in humans is encoded by the ARNT2 gene.

This gene encodes a member of the basic-helix-loop-helix-Per-Arnt-Sim (bHLH-PAS) superfamily of transcription factors. The encoded protein acts as a partner for several sensor proteins of the bHLH-PAS family, forming heterodimers with the sensor proteins that bind regulatory DNA sequences in genes responsive to developmental and environmental stimuli. Under hypoxic conditions, the encoded protein complexes with hypoxia-inducible factor 1alpha in the nucleus and this complex binds to hypoxia-responsive elements in enhancers and promoters of oxygen-responsive genes. A highly similar protein in mouse forms functional complexes with both aryl hydrocarbon receptors and Single-minded proteins, suggesting addition roles for the encoded protein in the metabolism of xenobiotic compounds and the regulation of neurogenesis, respectively.