ARPC3

Available protein structures:
Pfam	structures / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary

ARP2/3 complex ARPC3 (21 kDa) subunit
ARP2/3 complex ARPC3 (21 kDa) subunit
	crystal structure of arp2/3 complex with bound adp and calcium
Identifiers
Symbol	P21-Arc
Pfam	PF04062
InterPro	IPR007204
Pfam
Available protein structures:
Pfam	structures / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary

ARPC3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2P9N, 1TYQ, 1U2V, 4JD2, 3DXK, 3UKU, 3UKR, 2P9P, 2P9K, 2P9U, 3ULE, 3RSE, 2P9S, 2P9I, 4XF2, 2P9L, 1K8K, 3DXM, 4XEI
Identifiers
Aliases	ARPC3, ARC21, p21-Arc, actin related protein 2/3 complex subunit 3
External IDs	OMIM: 604225; MGI: 1928375; HomoloGene: 4178; GeneCards: ARPC3; OMA:ARPC3 - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	110,450,422 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	122,552,247 bp
RNA expression pattern
	Top expressed in
	monocyte; ; granulocyte; ; appendix; ; rectum; ; islet of Langerhans; ; gallbladder; ; right lung; ; mucosa of transverse colon; ; olfactory zone of nasal mucosa; ; smooth muscle tissue;
	Top expressed in
	granulocyte; ; superior surface of tongue; ; mesenteric lymph nodes; ; stroma of bone marrow; ; endothelial cell of lymphatic vessel; ; right lung lobe; ; thymus; ; mucous cell of stomach; ; spleen; ; medial ganglionic eminence;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	actin filament binding; structural constituent of cytoskeleton; protein binding; actin binding;
Cellular component	cytoplasm; cytosol; cell projection; membrane; focal adhesion; arp2/3 protein complex; actin cytoskeleton; extracellular exosome; cytoskeleton; lamellipodium; cell leading edge; filamentous actin; growth cone leading edge; nucleus; site of double-strand break;
Biological process	Fc-gamma receptor signaling pathway involved in phagocytosis; ephrin receptor signaling pathway; regulation of actin filament polymerization; Arp2/3 complex-mediated actin nucleation; cellular response to nerve growth factor stimulus; membrane organization; actin polymerization-dependent cell motility;
	Sources:Amigo / QuickGO
Orthologs
	10094
	56378
	ENSG00000111229
	ENSMUSG00000029465
	O15145
	Q9JM76
	NM_001287222; NM_001278556
	NM_019824
	NP_001265485; NP_001274151
	NP_062798
	Wikidata
View/Edit Human	View/Edit Mouse

Actin-related protein 2/3 complex subunit 3 is a protein that in humans is encoded by the ARPC3 gene.

This gene encodes one of seven subunits of the Arp2/3 protein complex. The Arp2/3 protein complex has been implicated in the control of actin polymerization in cells and has been conserved through evolution. The exact role of the protein encoded by this gene, the p21 subunit, has yet to be determined.