Arylsulfatase A

ARSA
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2HI8, 1AUK, 1E1Z, 1E2S, 1E33, 1E3C, 1N2K, 1N2L, 2AIJ, 2AIK
Identifiers
Aliases	ARSA, MLD, arylsulfatase A, ASA
External IDs	OMIM: 607574; MGI: 88077; HomoloGene: 20138; GeneCards: ARSA; OMA:ARSA - orthologs
Gene location (Human)
Chr.	Chromosome 22 (human)
End	50,628,173 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	89,361,628 bp
RNA expression pattern
	Top expressed in
	right uterine tube; ; right testis; ; granulocyte; ; mucosa of transverse colon; ; left testis; ; apex of heart; ; anterior pituitary; ; minor salivary glands; ; right lobe of thyroid gland; ; right hemisphere of cerebellum;
	Top expressed in
	spermatocyte; ; spermatid; ; seminiferous tubule; ; decidua; ; medial dorsal nucleus; ; left lobe of liver; ; calvaria; ; motor neuron; ; brown adipose tissue; ; lateral geniculate nucleus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	calcium ion binding; cerebroside-sulfatase activity; sulfuric ester hydrolase activity; protein binding; hydrolase activity; catalytic activity; metal ion binding; arylsulfatase activity;
Cellular component	lysosome; lysosomal lumen; extracellular exosome; endoplasmic reticulum lumen; extracellular region; azurophil granule lumen; endoplasmic reticulum;
Biological process	post-translational protein modification; metabolism; glycosphingolipid metabolic process; neutrophil degranulation;
	Sources:Amigo / QuickGO
Orthologs
	410
	11883
	ENSG00000100299
	ENSMUSG00000022620
	P15289
	P50428
NM_000487; NM_001085425; NM_001085426; NM_001085427; NM_001085428;
	NM_001362782
	NM_009713
NP_000478; NP_001078894; NP_001078895; NP_001078896; NP_001078897;
	NP_001349711
	NP_033843
	Wikidata
View/Edit Human	View/Edit Mouse

Arylsulfatase A (or cerebroside-sulfatase) is an enzyme that breaks down sulfatides, namely cerebroside 3-sulfate into cerebroside and sulfate. In humans, arylsulfatase A is encoded by the ARSA gene.