ASB2

ASB2
Identifiers
Aliases	ASB2, ASB-2, ankyrin repeat and SOCS box containing 2
External IDs	OMIM: 605759; MGI: 1929743; HomoloGene: 69202; GeneCards: ASB2; OMA:ASB2 - orthologs
Gene location (Human)
Chr.	Chromosome 14 (human)
End	93,976,739 bp
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	103,322,260 bp
RNA expression pattern
	Top expressed in
	skeletal muscle tissue; ; gastrocnemius muscle; ; muscle of thigh; ; apex of heart; ; left ventricle; ; smooth muscle tissue; ; muscle layer of sigmoid colon; ; right auricle of heart; ; left uterine tube; ; right coronary artery;
	Top expressed in
	knee joint; ; muscle of thigh; ; vastus lateralis muscle; ; triceps brachii muscle; ; temporal muscle; ; myocardium of ventricle; ; tibialis anterior muscle; ; sternocleidomastoid muscle; ; digastric muscle; ; skeletal muscle tissue;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; ubiquitin protein ligase activity;
Cellular component	Cul5-RING ubiquitin ligase complex; cytosol; ubiquitin ligase complex;
Biological process	skeletal muscle cell differentiation; myoblast differentiation; intracellular signal transduction; protein polyubiquitination; signal transduction; post-translational protein modification; protein ubiquitination; ubiquitin-dependent protein catabolic process;
	Sources:Amigo / QuickGO
Orthologs
	51676
	65256
	ENSG00000100628; ENSG00000278693
	ENSMUSG00000021200
	Q96Q27
	Q8K0L0
	NM_001202429; NM_016150
	NM_023049; NM_001374764
	NP_001189358; NP_057234
	NP_075536; NP_001361693
	Wikidata
View/Edit Human	View/Edit Mouse

Ankyrin repeat and SOCS box protein 2 (ASBS) is a protein that is encoded by the ASB2 gene in humans.

The ASB2 protein belongs to the ankyrin repeat and SOCS box-containing (ASB) family of proteins. It consists of an ankyrin repeat sequence and a SOCS box domain. The SOCS box plays a role in connecting suppressor of cytokine signaling (SOCS) proteins and their binding partners with the elongin B and C complex, potentially facilitating their degradation. This gene is induced by all-trans retinoic acid. In myeloid leukemia cells, the expression of this encoded protein has been shown to induce growth inhibition and chromatin condensation. Multiple alternatively spliced transcript variants have been described for this gene but their full length sequences are not known.