ASCL1

ASCL1
Identifiers
Aliases	ASCL1, ASH1, HASH1, MASH1, bHLHa46, achaete-scute family bHLH transcription factor 1
External IDs	OMIM: 100790; MGI: 96919; HomoloGene: 31234; GeneCards: ASCL1; OMA:ASCL1 - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	102,960,513 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	87,329,522 bp
RNA expression pattern
	Top expressed in
	ganglionic eminence; ; ventricular zone; ; Region I of hippocampus proper; ; entorhinal cortex; ; external globus pallidus; ; primary visual cortex; ; Amygdala; ; postcentral gyrus; ; ventral tegmental area; ; pituitary gland;
	Top expressed in
	medial ganglionic eminence; ; rhombic lip; ; ventricular zone; ; pituitary gland; ; Rostral migratory stream; ; pelvic ganglion; ; enteric nervous system; ; female urethra; ; anterior pituitary; ; male urethra;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	DNA binding; sequence-specific DNA binding; protein dimerization activity; protein homodimerization activity; DNA-binding transcription factor activity; chromatin binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; DNA-binding transcription repressor activity, RNA polymerase II-specific; bHLH transcription factor binding; E-box binding; protein binding; double-stranded DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II transcription regulatory region sequence-specific DNA binding; transcription factor binding;
Cellular component	soma; nucleus; RNA polymerase II transcription regulator complex;
Biological process	Notch signaling pathway; commitment of neuronal cell to specific neuron type in forebrain; sympathetic ganglion development; pattern specification process; noradrenergic neuron development; cerebral cortex GABAergic interneuron differentiation; neurogenesis; cell differentiation; stomach neuroendocrine cell differentiation; regulation of transcription, DNA-templated; negative regulation of neuron differentiation; response to retinoic acid; spinal cord association neuron differentiation; sympathetic nervous system development; neuroblast fate determination; regulation of transcription by RNA polymerase II; spinal cord oligodendrocyte cell fate specification; musculoskeletal movement, spinal reflex action; negative regulation of apoptotic process; neuron migration; glial cell differentiation; negative regulation of transcription by RNA polymerase II; cell maturation; cellular response to magnetism; oligodendrocyte differentiation; olfactory pit development; transcription, DNA-templated; lung neuroendocrine cell differentiation; nervous system development; generation of neurons; response to lithium ion; multicellular organism development; positive regulation of neural precursor cell proliferation; adrenal chromaffin cell differentiation; positive regulation of neurogenesis; positive regulation of neuron apoptotic process; ventral spinal cord interneuron fate commitment; central nervous system neuron development; positive regulation of cell cycle; response to epidermal growth factor; regulation of cell population proliferation; vestibular nucleus development; positive regulation of neuron differentiation; regulation of mitotic cell cycle; forebrain neuron differentiation; cerebral cortex development; regulation of gene expression; neuroblast proliferation; subpallium neuron fate commitment; regulation of timing of subpallium neuron differentiation; oligodendrocyte development; lung epithelial cell differentiation; carotid body glomus cell differentiation; response to folic acid; spinal cord oligodendrocyte cell differentiation; regulation of epithelial cell differentiation; negative regulation of transcription, DNA-templated; noradrenergic neuron fate commitment; regulation of Notch signaling pathway; regulation of neurogenesis; positive regulation of Notch signaling pathway; positive regulation of transcription by RNA polymerase II; oligodendrocyte cell fate commitment; neuron differentiation; neuron fate commitment; neuron fate specification; neuron development; heart development; sensory organ development;
	Sources:Amigo / QuickGO
Orthologs
	429
	17172
	ENSG00000139352
	ENSMUSG00000020052
	P50553
	Q02067
	NM_004316
	NM_008553
	NP_004307
	NP_032579
	Wikidata
View/Edit Human	View/Edit Mouse

Achaete-scute homolog 1 is a protein that in humans is encoded by the ASCL1 gene. Because it was discovered subsequent to studies on its homolog in Drosophila, the Achaete-scute complex, it was originally named MASH-1 for mammalian achaete scute homolog-1.