ASIC1

ASIC1
Identifiers
Aliases	ASIC1, ACCN2, ASIC, BNaC2, acid sensing ion channel subunit 1
External IDs	OMIM: 602866; MGI: 1194915; HomoloGene: 121755; GeneCards: ASIC1; OMA:ASIC1 - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	50,083,611 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	99,599,011 bp
RNA expression pattern
	Top expressed in
	right hemisphere of cerebellum; ; ganglionic eminence; ; putamen; ; caudate nucleus; ; nucleus accumbens; ; right frontal lobe; ; Amygdala; ; Hypothalamus; ; prefrontal cortex; ; Brodmann area 9;
	Top expressed in
	superior frontal gyrus; ; cerebellar cortex; ; primary visual cortex; ; trigeminal ganglion; ; nucleus accumbens; ; central gray substance of midbrain; ; superior colliculus; ; Rostral migratory stream; ; facial motor nucleus; ; dentate gyrus of hippocampal formation granule cell;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	ion gated channel activity; sodium channel activity; ion channel activity; protein binding; cation channel activity; ligand-gated sodium channel activity; acid-sensing ion channel activity;
Cellular component	integral component of membrane; membrane; synapse; integral component of plasma membrane; cell surface; Golgi apparatus; plasma membrane;
Biological process	negative regulation of neurotransmitter secretion; associative learning; sodium ion transmembrane transport; sodium ion transport; regulation of membrane potential; cation transport; memory; sensory perception of sour taste; ion transport; protein homotrimerization; ion transmembrane transport; cellular response to pH; calcium ion transmembrane transport; response to pH; signal transduction; response to acidic pH; calcium ion transport; behavioral fear response; response to amphetamine;
	Sources:Amigo / QuickGO
Orthologs
	41
	11419
	ENSG00000110881
	ENSMUSG00000023017
	P78348
	Q6NXK8
	NM_001095; NM_001256830; NM_020039
	NM_001289791; NM_009597
	NP_001086; NP_001243759; NP_064423
	NP_001276720; NP_033727
	Wikidata
View/Edit Human	View/Edit Mouse

Acid-sensing ion channel 1 (ASIC1) also known as amiloride-sensitive cation channel 2, neuronal (ACCN2) or brain sodium channel 2 (BNaC2) is a protein that in humans is encoded by the ASIC1 gene. The ASIC1 gene is one of the five paralogous genes that encode proteins that form trimeric acid-sensing ion channels (ASICs) in mammals. The cDNA of this gene was first cloned in 1996. The ASIC genes have splicing variants that encode different proteins that are called isoforms.

These genes are mainly expressed in the central and peripheral nervous system.

ASICs can form both homotrimeric (meaning composed of three identical subunits) and heterotrimeric channels.