ASIC2

ASIC2
Identifiers
Aliases	ASIC2, ACCN, ACCN1, ASIC2a, BNC1, BNaC1, MDEG, hBNaC1, acid sensing ion channel subunit 2
External IDs	OMIM: 601784; MGI: 1100867; HomoloGene: 137202; GeneCards: ASIC2; OMA:ASIC2 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	34,174,964 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	81,859,283 bp
RNA expression pattern
	Top expressed in
	prefrontal cortex; ; cingulate gyrus; ; anterior cingulate cortex; ; Brodmann area 9; ; cerebellar cortex; ; cerebellar hemisphere; ; right hemisphere of cerebellum; ; Brodmann area 10; ; Brodmann area 46; ; orbitofrontal cortex;
	Top expressed in
	perirhinal cortex; ; entorhinal cortex; ; CA3 field; ; primary motor cortex; ; dorsomedial hypothalamic nucleus; ; primary visual cortex; ; central gray substance of midbrain; ; paraventricular nucleus of hypothalamus; ; cingulate gyrus; ; lateral hypothalamus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	ion gated channel activity; sodium channel activity; ion channel activity; protein binding; cation channel activity; ligand-gated sodium channel activity; acid-sensing ion channel activity;
Cellular component	integral component of membrane; membrane; plasma membrane; dendritic spine; integral component of plasma membrane; synapse; soma; neuron projection;
Biological process	chemical synaptic transmission; positive regulation of synapse assembly; peripheral nervous system development; sodium ion transmembrane transport; detection of mechanical stimulus involved in sensory perception; sodium ion transport; regulation of membrane potential; regulation of ion transmembrane transport; response to mechanical stimulus; negative regulation of apoptotic process; cation transport; hearing; sensory perception of sour taste; ion transport; cation transmembrane transport; central nervous system development; ion transmembrane transport; regulation of vasoconstriction; protein localization to synapse; response to acidic pH; phototransduction; regulation of systemic arterial blood pressure by aortic arch baroreceptor feedback;
	Sources:Amigo / QuickGO
Orthologs
	40
	11418
	ENSG00000108684
	ENSMUSG00000020704
	Q16515
	Q925H0
	NM_183377; NM_001094
	NM_001034013; NM_007384
	NP_001085; NP_899233
	NP_001029185; NP_031410
	Wikidata
View/Edit Human	View/Edit Mouse

Acid-sensing ion channel 2 (ASIC2) also known as amiloride-sensitive cation channel 1, neuronal (ACCN1) or brain sodium channel 1 (BNaC1) is a protein that in humans is encoded by the ASIC2 gene. The ASIC2 gene is one of the five paralogous genes that encode proteins that form trimeric acid-sensing ion channels (ASICs) in mammals. The cDNA of this gene was first cloned in 1996. The ASIC genes have splicing variants that encode different proteins that are called isoforms.

These genes are mainly expressed in the central and peripheral nervous system.

ASICs can form both homotrimeric (meaning composed of three identical subunits) and heterotrimeric channels.