ASIC3

ASIC3
Identifiers
Aliases	ASIC3, ACCN3, DRASIC, SLNAC1, TNaC1, acid sensing ion channel subunit 3
External IDs	OMIM: 611741; MGI: 2159339; HomoloGene: 20999; GeneCards: ASIC3; OMA:ASIC3 - orthologs
Gene location (Human)
Chr.	Chromosome 7 (human)
End	151,052,756 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	24,622,833 bp
RNA expression pattern
	Top expressed in
	right hemisphere of cerebellum; ; right testis; ; left testis; ; right frontal lobe; ; apex of heart; ; C1 segment; ; anterior pituitary; ; nucleus accumbens; ; caudate nucleus; ; putamen;
	Top expressed in
	lumbar spinal ganglion; ; neural layer of retina; ; vestibular membrane of cochlear duct; ; cochlea; ; morula; ; trigeminal ganglion; ; embryo; ; embryo; ; blastocyst; ; pineal gland;
	More reference expression data
	n/a
Gene ontology
Molecular function	PDZ domain binding; enterobactin transmembrane transporter activity; sodium channel activity; cation channel activity; ligand-gated sodium channel activity; acid-sensing ion channel activity;
Cellular component	cytoplasm; integral component of membrane; membrane; plasma membrane; integral component of plasma membrane; perinuclear region of cytoplasm;
Biological process	detection of temperature stimulus involved in sensory perception; sensory perception; sodium ion transmembrane transport; detection of chemical stimulus involved in sensory perception of pain; detection of mechanical stimulus involved in sensory perception; sodium ion transport; enterobactin transport; response to mechanical stimulus; cation transport; response to heat; sensory perception of sour taste; ion transport; detection of chemical stimulus involved in sensory perception; cation transmembrane transport; detection of temperature stimulus involved in sensory perception of pain; ion transmembrane transport; signal transduction; response to acidic pH; detection of mechanical stimulus involved in sensory perception of pain;
	Sources:Amigo / QuickGO
Orthologs
	9311
	171209
	ENSG00000213199
	ENSMUSG00000038276
	Q9UHC3
	Q6X1Y6
	NM_004769; NM_020321; NM_020322
	NM_183000; NM_001310474
	NP_004760; NP_064717; NP_064718
	NP_001297403; NP_892045
	Wikidata
View/Edit Human	View/Edit Mouse

Acid-sensing ion channel 3 (ASIC3) also known as amiloride-sensitive cation channel 3 (ACCN3) or testis sodium channel 1 (TNaC1) is a protein that in humans is encoded by the ASIC3 gene. The ASIC3 gene is one of the five paralogous genes that encode proteins that form trimeric acid-sensing ion channels (ASICs) in mammals. The cDNA of this gene was first cloned in 1998. The ASIC genes have splicing variants that encode different proteins that are called isoforms.

These genes are mainly expressed in the central and peripheral nervous system.

ASICs can form both homotrimeric (meaning composed of three identical subunits) and heterotrimeric channels.