ASK1

MAP3K5
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2CLQ, 3VW6, 4BF2, 4BHN, 4BIB, 4BIC, 4BID, 4BIE
Identifiers
Aliases	MAP3K5, ASK1, MAPKKK5, MEKK5, mitogen-activated protein kinase kinase kinase 5
External IDs	OMIM: 602448; MGI: 1346876; HomoloGene: 38114; GeneCards: MAP3K5; OMA:MAP3K5 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	136,792,477 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	20,018,499 bp
RNA expression pattern
	Top expressed in
	endothelial cell; ; Brodmann area 23; ; decidua; ; pancreatic ductal cell; ; adrenal cortex; ; left adrenal gland; ; right adrenal gland; ; left adrenal cortex; ; right adrenal cortex; ; dorsal motor nucleus of vagus nerve;
	Top expressed in
	ciliary body; ; cumulus cell; ; pineal gland; ; retinal pigment epithelium; ; hair follicle; ; granulocyte; ; iris; ; transitional epithelium of urinary bladder; ; ascending aorta; ; vestibular membrane of cochlear duct;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	transferase activity; protein kinase activity; nucleotide binding; protein homodimerization activity; metal ion binding; kinase activity; protein binding; protein phosphatase binding; MAP kinase kinase kinase activity; ATP binding; protein kinase binding; magnesium ion binding; protein serine/threonine kinase activity; protein domain specific binding; identical protein binding;
Cellular component	cytoplasm; protein kinase complex; endoplasmic reticulum; IRE1-TRAF2-ASK1 complex; cytosol; external side of plasma membrane; protein-containing complex;
Biological process	intrinsic apoptotic signaling pathway in response to oxidative stress; positive regulation of protein phosphorylation; phosphorylation; immune system process; regulation of cell death; positive regulation of neuron death; positive regulation of JNK cascade; response to endoplasmic reticulum stress; cellular response to reactive nitrogen species; MAPK cascade; protein phosphorylation; JNK cascade; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; response to ischemia; positive regulation of myoblast differentiation; positive regulation of apoptotic process; apoptotic signaling pathway; p38MAPK cascade; programmed necrotic cell death; innate immune response; viral process; cellular response to hydrogen peroxide; apoptotic process; cellular response to tumor necrosis factor; positive regulation of cardiac muscle cell apoptotic process; positive regulation of p38MAPK cascade; wound healing; positive regulation of JUN kinase activity; positive regulation of vascular associated smooth muscle cell proliferation; endothelial cell apoptotic process; cellular response to amino acid starvation; positive regulation of transcription, DNA-templated; stress-activated MAPK cascade;
	Sources:Amigo / QuickGO
Orthologs
	4217
	26408
	ENSG00000197442
	ENSMUSG00000071369
	Q99683
	O35099
	NM_005923
	NM_008580
	NP_005914
	NP_032606
	Wikidata
View/Edit Human	View/Edit Mouse

Apoptosis signal-regulating kinase 1 (ASK1) also known as mitogen-activated protein kinase kinase kinase 5 (MAP3K5) is a member of MAP kinase family and as such a part of mitogen-activated protein kinase pathway. It activates c-Jun N-terminal kinase (JNK) and p38 mitogen-activated protein kinases in a Raf-independent fashion in response to an array of stresses such as oxidative stress, endoplasmic reticulum stress and calcium influx. ASK1 has been found to be involved in cancer, diabetes, rheumatoid arthritis, cardiovascular and neurodegenerative diseases.

MAP3K5 gene coding for the protein is located on chromosome 6 at locus 6q22.33. and the transcribed protein contains 1,374 amino acids with 11 kinase subdomains. Northern blot analysis shows that MAP3K5 transcript is abundant in human heart and pancreas.