ASTL

ASTL
Identifiers
Aliases	ASTL, SAS1B, astacin-like metallo-endopeptidase (M12 family), astacin like metalloendopeptidase, OOMD11, Ovastacin, Oocyte astacin
External IDs	OMIM: 608860; MGI: 3046414; HomoloGene: 128191; GeneCards: ASTL; OMA:ASTL - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	96,138,502 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	127,199,571 bp
RNA expression pattern
	Top expressed in
	bone marrow; ; bone marrow cells; ; gonad; ; olfactory zone of nasal mucosa; ; blood; ; skin of abdomen; ; granulocyte; ; skin of leg; ; spleen; ; right lung;
	Top expressed in
	primary oocyte; ; secondary oocyte; ; zygote; ; embryo; ; morula; ; blastocyst; ; ovary; ; cumulus cell;
	More reference expression data
	n/a
Gene ontology
Molecular function	peptidase activity; glutamic-type peptidase activity; metallopeptidase activity; hydrolase activity; metalloendopeptidase activity; zinc ion binding; aspartic-type peptidase activity; metal ion binding;
Cellular component	plasma membrane; transport vesicle; cytoplasm; membrane; cytoplasmic vesicle; cortical granule;
Biological process	fertilization; positive regulation of protein processing; prevention of polyspermy; proteolysis; negative regulation of binding of sperm to zona pellucida; single fertilization; cell adhesion;
	Sources:Amigo / QuickGO
Orthologs
	431705
	215095
	ENSG00000188886
	ENSMUSG00000050468
	Q6HA08
	Q6HA09
	NM_001002036
	NM_001291003; NM_172539
	NP_001002036
	NP_001277932; NP_766127
	Wikidata
View/Edit Human	View/Edit Mouse

Astacin-like metalloendopeptidase is a protein that in humans is encoded by the ASTL gene.