ATF4

ATF4
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1CI6
Identifiers
Aliases	ATF4, CREB-2, CREB2, TAXREB67, TXREB, activating transcription factor 4
External IDs	OMIM: 604064; MGI: 88096; HomoloGene: 1266; GeneCards: ATF4; OMA:ATF4 - orthologs
Gene location (Human)
Chr.	Chromosome 22 (human)
End	39,522,683 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	80,141,742 bp
RNA expression pattern
	Top expressed in
	muscle layer of sigmoid colon; ; popliteal artery; ; tibial arteries; ; body of stomach; ; subcutaneous adipose tissue; ; fundus; ; right coronary artery; ; body of pancreas; ; left coronary artery; ; Descending thoracic aorta;
	Top expressed in
	ankle joint; ; calvaria; ; fetal liver hematopoietic progenitor cell; ; granulocyte; ; lacrimal gland; ; plantaris muscle; ; temporal muscle; ; islet of Langerhans; ; triceps brachii muscle; ; muscle of thigh;
	More reference expression data
	n/a
Gene ontology
Molecular function	DNA binding; sequence-specific DNA binding; DNA-binding transcription factor activity; DNA-binding transcription activator activity, RNA polymerase II-specific; transcription factor binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; core promoter sequence-specific DNA binding; protein C-terminus binding; protein binding; leucine zipper domain binding; protein heterodimerization activity; protein kinase binding; DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II transcription regulatory region sequence-specific DNA binding;
Cellular component	cytoplasm; ATF1-ATF4 transcription factor complex; ATF4-CREB1 transcription factor complex; transcription regulator complex; dendrite membrane; nucleus; Lewy body core; nuclear periphery; membrane; plasma membrane; nucleoplasm; microtubule organizing center; neuron projection; cytoskeleton; CHOP-ATF4 complex; centrosome; protein-containing complex; RNA polymerase II transcription regulator complex;
Biological process	gamma-aminobutyric acid signaling pathway; gluconeogenesis; regulation of transcription, DNA-templated; positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress; regulation of transcription by RNA polymerase II; negative regulation of oxidative stress-induced neuron death; cellular response to amino acid starvation; mRNA transcription by RNA polymerase II; circadian regulation of gene expression; response to endoplasmic reticulum stress; PERK-mediated unfolded protein response; response to manganese-induced endoplasmic reticulum stress; positive regulation of transcription, DNA-templated; positive regulation of neuron apoptotic process; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; positive regulation of gene expression; positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress; circadian rhythm; negative regulation of potassium ion transport; positive regulation of transcription by RNA polymerase II; positive regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance; cellular response to glucose starvation; negative regulation of translational initiation in response to stress; rhythmic process; cellular response to UV; positive regulation of transcription from RNA polymerase II promoter in response to stress; cellular amino acid metabolic process; transcription by RNA polymerase II; transcription, DNA-templated; positive regulation of apoptotic process; positive regulation of vascular endothelial growth factor production; positive regulation of transcription by RNA polymerase I; cellular response to dopamine; response to toxic substance; neuron differentiation; cellular response to oxygen-glucose deprivation; positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway; cellular calcium ion homeostasis; positive regulation of biomineral tissue development; negative regulation of cold-induced thermogenesis; positive regulation of vascular associated smooth muscle cell apoptotic process; positive regulation of sodium-dependent phosphate transport;
	Sources:Amigo / QuickGO
Orthologs
	468
	11911
	ENSG00000128272
	ENSMUSG00000042406
	P18848
	Q06507
	NM_182810; NM_001675
	NM_001287180; NM_009716
	NP_001666; NP_877962
	NP_001274109; NP_033846
	Wikidata
View/Edit Human	View/Edit Mouse

Activating transcription factor 4 (tax-responsive enhancer element B67), also known as ATF4, is a protein that in humans is encoded by the ATF4 gene.