ATG16L1

ATG16L1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4GDK, 4GDL, 4NAW, 4TQ0, 5D7G
Identifiers
Aliases	ATG16L1, autophagy related 16-like 1 (S. cerevisiae), APG16L, ATG16A, ATG16L, IBD10, WDR30, autophagy related 16 like 1
External IDs	OMIM: 610767; MGI: 1924290; HomoloGene: 41786; GeneCards: ATG16L1; OMA:ATG16L1 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	233,295,674 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	87,720,150 bp
RNA expression pattern
	Top expressed in
	right hemisphere of cerebellum; ; testicle; ; gonad; ; granulocyte; ; right frontal lobe; ; right lobe of thyroid gland; ; left lobe of thyroid gland; ; skin of leg; ; gastrocnemius muscle; ; skin of abdomen;
	Top expressed in
	neural layer of retina; ; secondary oocyte; ; primary oocyte; ; granulocyte; ; motor neuron; ; superior frontal gyrus; ; primary visual cortex; ; right ventricle; ; transitional epithelium of urinary bladder; ; dentate gyrus of hippocampal formation granule cell;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	ubiquitin-like protein transferase activity; protein binding; identical protein binding; GTPase binding;
Cellular component	cytoplasm; autophagosome; axoneme; cytosol; phagophore assembly site membrane; autophagosome membrane; membrane;
Biological process	protein transport; autophagy; negative stranded viral RNA replication; protein homooligomerization; macroautophagy; autophagosome assembly; protein localization to phagophore assembly site; protein lipidation involved in autophagosome assembly; xenophagy; positive regulation of autophagy;
	Sources:Amigo / QuickGO
Orthologs
	55054
	77040
	ENSG00000281089; ENSG00000085978
	ENSMUSG00000026289
	Q676U5
	Q8C0J2
NM_001190266; NM_001190267; NM_017974; NM_030803; NM_198890;
	NM_001363742
	NM_001205391; NM_001205392; NM_029846
NP_001177195; NP_001177196; NP_060444; NP_110430; NP_942593;
	NP_001350671; NP_060444.3
	NP_001192320; NP_001192321; NP_084122
	Wikidata
View/Edit Human	View/Edit Mouse

Autophagy related 16 like 1 is a protein that in humans is encoded by the ATG16L1 gene. This protein is characterized as a subunit of the autophagy-related ATG12-ATG5/ATG16 complex and is essentially important for the LC3 (ATG8) lipidation and autophagosome formation. This complex localizes to the membrane and is released just before or after autophagosome completion.

Furthermore, ATG16L1 appears to have other autophagy-independent functions, e.g., intracellular membrane trafficking regulation and inflammation. Autophagy in general plays a crucial role in pathways leading to innate and adaptive immunity activation. That is why many autophagy-related proteins, including ATG16L1, their gene expression and its role in autoimmune diseases are studied in-depth nowadays.