Atlastin

Atlastins (ATLs) are a class of endoplasmic reticulum (ER) GTPases. Invertebrates have a single ATL, while vertebrates possess three ATL proteins (ATL1-3) that are differentially expressed. ATL1 is the predominant paralog of the central nervous system, whereas ATL2 and ATL3 are mainly expressed in tissues outside of the CNS. Loss of all ATLs in mammalian cells dramatically impacts ER structure, including a reduction in tubule three-way junctions.

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