Atrophin 1

ATN1
Identifiers
Aliases	ATN1, B37, D12S755E, DRPLA, HRS, NOD, atrophin 1, CHEDDA
External IDs	OMIM: 607462; MGI: 104725; HomoloGene: 1461; GeneCards: ATN1; OMA:ATN1 - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	6,942,321 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	124,733,487 bp
RNA expression pattern
	Top expressed in
	right hemisphere of cerebellum; ; anterior pituitary; ; left ovary; ; right uterine tube; ; right ovary; ; right lobe of thyroid gland; ; left lobe of thyroid gland; ; body of uterus; ; gastric mucosa; ; canal of the cervix;
	Top expressed in
	neural layer of retina; ; primary visual cortex; ; superior frontal gyrus; ; genital tubercle; ; dentate gyrus of hippocampal formation granule cell; ; cerebellar cortex; ; muscle of thigh; ; lip; ; ventricular zone; ; tail of embryo;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	protein binding; transcription corepressor activity; protein domain specific binding; DNA binding;
Cellular component	nuclear matrix; perinuclear region of cytoplasm; cell junction; nucleoplasm; cytoplasm; nucleus;
Biological process	neuron apoptotic process; central nervous system development; regulation of transcription, DNA-templated; negative regulation of transcription by RNA polymerase II; transcription, DNA-templated;
	Sources:Amigo / QuickGO
Orthologs
	1822
	13498
	ENSG00000111676
	ENSMUSG00000004263
	P54259
	O35126
	NM_001940; NM_001007026
	NM_007881
	NP_001007027; NP_001931
	NP_031907
	Wikidata
View/Edit Human	View/Edit Mouse

Atrophin-1 is a protein that in humans is encoded by the ATN1 gene. The encoded protein includes a serine repeat and a region of alternating acidic and basic amino acids, as well as the variable glutamine repeat. The function of Atrophin-1 has not yet been determined. There is evidence provided by studies of Atrophin-1 in animals to suggest it acts as a transcriptional co-repressor. Atrophin-1 can be found in the nuclear and cytoplasmic compartments of neurons. It is expressed in nervous tissue.