ATP2A1

ATP2A1
Identifiers
Aliases	ATP2A1, ATP2A, SERCA1, ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1
External IDs	OMIM: 108730; MGI: 105058; HomoloGene: 7635; GeneCards: ATP2A1; OMA:ATP2A1 - orthologs
Gene location (Human)
Chr.	Chromosome 16 (human)
End	28,904,466 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	126,062,280 bp
RNA expression pattern
	Top expressed in
	muscle of thigh; ; Skeletal muscle tissue of rectus abdominis; ; thoracic diaphragm; ; Skeletal muscle tissue of biceps brachii; ; vastus lateralis muscle; ; triceps brachii muscle; ; gastrocnemius muscle; ; body of tongue; ; glutes; ; deltoid muscle;
	Top expressed in
	ankle; ; triceps brachii muscle; ; temporal muscle; ; sternocleidomastoid muscle; ; digastric muscle; ; muscle of thigh; ; vastus lateralis muscle; ; extensor digitorum longus muscle; ; tibialis anterior muscle; ; medial head of gastrocnemius muscle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; calcium ion binding; protein homodimerization activity; metal ion binding; protein binding; hydrolase activity; ATP binding; P-type calcium transporter activity; ATPase activity; P-type proton-exporting transporter activity;
Cellular component	integral component of membrane; endoplasmic reticulum membrane; membrane; I band; calcium channel complex; H zone; sarcoplasmic reticulum; platelet dense tubular network membrane; endoplasmic reticulum; sarcoplasmic reticulum membrane; perinuclear region of cytoplasm; endoplasmic reticulum-Golgi intermediate compartment; mitochondrion;
Biological process	regulation of cardiac conduction; positive regulation of fast-twitch skeletal muscle fiber contraction; negative regulation of striated muscle contraction; calcium ion import; positive regulation of endoplasmic reticulum calcium ion concentration; ion transport; response to endoplasmic reticulum stress; maintenance of mitochondrion location; ion transmembrane transport; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; regulation of striated muscle contraction; apoptotic mitochondrial changes; relaxation of skeletal muscle; negative regulation of endoplasmic reticulum calcium ion concentration; positive regulation of mitochondrial calcium ion concentration; calcium ion transport; calcium ion transmembrane transport; cellular calcium ion homeostasis; proton transmembrane transport; calcium ion import into sarcoplasmic reticulum; positive regulation of cardiac muscle cell contraction; positive regulation of ATPase-coupled calcium transmembrane transporter activity; positive regulation of calcium ion import into sarcoplasmic reticulum;
	Sources:Amigo / QuickGO
Orthologs
	487
	11937
	ENSG00000196296
	ENSMUSG00000030730
	O14983
	Q8R429
	NM_173201; NM_001286075; NM_004320
	NM_007504
	NP_001273004; NP_004311; NP_775293
	NP_031530
	Wikidata
View/Edit Human	View/Edit Mouse

Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 (SERCA1) also known as Calcium pump 1, is an enzyme that in humans is encoded by the ATP2A1 gene.