ATP5PO

ATP5PO
Identifiers
Aliases	ATP5PO, ATPO, OSCP, HMC08D05, ATP synthase, H+ transporting, mitochondrial F1 complex, O subunit, ATP synthase peripheral stalk subunit OSCP, ATP5O
External IDs	OMIM: 600828; MGI: 106341; HomoloGene: 1283; GeneCards: ATP5PO; OMA:ATP5PO - orthologs
Gene location (Human)
Chr.	Chromosome 21 (human)
End	33,915,814 bp
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	91,728,575 bp
RNA expression pattern
	Top expressed in
	left ventricle; ; apex of heart; ; right auricle of heart; ; ganglionic eminence; ; gastrocnemius muscle; ; mucosa of transverse colon; ; muscle of thigh; ; rectum; ; dorsolateral prefrontal cortex; ; body of stomach;
	Top expressed in
	endocardial cushion; ; atrioventricular valve; ; myocardium of ventricle; ; muscle of thigh; ; intercostal muscle; ; yolk sac; ; soleus muscle; ; spermatocyte; ; right kidney; ; atrium;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	proton-transporting ATP synthase activity, rotational mechanism; transmembrane transporter activity; transporter activity; ATPase activity; protein binding;
Cellular component	mitochondrial proton-transporting ATP synthase complex; membrane; plasma membrane; mitochondrion; mitochondrial inner membrane; extracellular exosome; nucleus; extracellular matrix;
Biological process	mitochondrial ATP synthesis coupled proton transport; ion transport; ATP synthesis coupled proton transport; ATP biosynthetic process; cristae formation; transport; proton transmembrane transport;
	Sources:Amigo / QuickGO
Orthologs
	539
	28080
	ENSG00000241837
	ENSMUSG00000022956
	P48047
	Q9DB20
	NM_001697
	NM_138597
	NP_001688
	NP_613063
	Wikidata
View/Edit Human	View/Edit Mouse

ATP synthase subunit O, mitochondrial is an enzyme that in humans is encoded by the ATP5PO gene.

The protein encoded by this gene is a component of the F-type ATPase found in the mitochondrial matrix. F-type ATPases are composed of a catalytic core and a membrane proton channel. The encoded protein appears to be part of the connector linking these two components and may be involved in transmission of conformational changes or proton conductance.