ATP6V0D1

ATP6V0D1
Identifiers
Aliases	ATP6V0D1, ATP6D, ATP6DV, P39, VATX, VMA6, VPATPD, ATPase H+ transporting V0 subunit d1
External IDs	OMIM: 607028; MGI: 1201778; HomoloGene: 3444; GeneCards: ATP6V0D1; OMA:ATP6V0D1 - orthologs
Gene location (Human)
Chr.	Chromosome 16 (human)
End	67,481,181 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	106,292,679 bp
RNA expression pattern
	Top expressed in
	mucosa of transverse colon; ; beta cell; ; lateral nuclear group of thalamus; ; granulocyte; ; mononuclear cell; ; monocyte; ; pars compacta; ; prefrontal cortex; ; right frontal lobe; ; lower lobe of lung;
	Top expressed in
	facial motor nucleus; ; anterior horn of spinal cord; ; stroma of bone marrow; ; hippocampus proper; ; superior frontal gyrus; ; epithelium of lens; ; central gray substance of midbrain; ; subiculum; ; temporal lobe; ; primary motor cortex;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein-containing complex binding; protein binding; proton transmembrane transporter activity; P-type proton-exporting transporter activity; proton-transporting ATPase activity, rotational mechanism;
Cellular component	axon terminus; proton-transporting V-type ATPase, V0 domain; phagocytic vesicle membrane; centrosome; membrane; synaptic vesicle; lysosomal membrane; apical plasma membrane; neuron projection; vacuolar proton-transporting V-type ATPase complex; endosome membrane; extracellular exosome; early endosome; protein-containing complex; plasma membrane proton-transporting V-type ATPase complex;
Biological process	insulin receptor signaling pathway; transferrin transport; ion transport; ion transmembrane transport; IRE1-mediated unfolded protein response; brain development; cell projection organization; regulation of macroautophagy; phagosome acidification; cilium assembly; vacuolar transport; vacuolar acidification; cellular iron ion homeostasis; cellular response to increased oxygen levels; transport; proton transmembrane transport;
	Sources:Amigo / QuickGO
Orthologs
	9114
	11972
	ENSG00000159720
	ENSMUSG00000013160
	P61421
	P51863
	NM_004691
	NM_013477
	NP_004682
	NP_038505
	Wikidata
View/Edit Human	View/Edit Mouse

V-type proton ATPase subunit d 1 is an enzyme that in humans is encoded by the ATP6V0D1 gene.

This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c'', and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This encoded protein is known as the D subunit and is found ubiquitously.