Wilson disease protein

ATP7B
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2ROP, 2EW9, 2KOY, 2LQB
Identifiers
Aliases	ATP7B, PWD, WC1, WD, WND, ATPase copper transporting beta
External IDs	OMIM: 606882; MGI: 103297; HomoloGene: 20063; GeneCards: ATP7B; OMA:ATP7B - orthologs
Gene location (Human)
Chr.	Chromosome 13 (human)
End	52,012,125 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	22,550,321 bp
RNA expression pattern
	Top expressed in
	nasal epithelium; ; right testis; ; left testis; ; olfactory zone of nasal mucosa; ; jejunal mucosa; ; right lobe of liver; ; germinal epithelium; ; gonad; ; testicle; ; right hemisphere of cerebellum;
	Top expressed in
	yolk sac; ; pharynx; ; gastrula; ; lumbar subsegment of spinal cord; ; urethra; ; right lung; ; right lung lobe; ; submandibular gland; ; left lung lobe; ; respiratory epithelium;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; metal ion binding; P-type divalent copper transporter activity; ATPase-coupled cation transmembrane transporter activity; protein binding; copper ion binding; hydrolase activity; ATP binding; copper ion transmembrane transporter activity;
Cellular component	cytoplasm; integral component of membrane; trans-Golgi network membrane; membrane; Golgi membrane; integral component of plasma membrane; trans-Golgi network; basolateral plasma membrane; mitochondrion; perinuclear region of cytoplasm; endosome; late endosome; Golgi apparatus; cytoplasmic vesicle;
Biological process	protein maturation by copper ion transfer; copper ion transmembrane transport; metal ion transport; copper ion import; cation transport; ion transport; copper ion export; ion transmembrane transport; sequestering of calcium ion; cellular zinc ion homeostasis; cellular copper ion homeostasis; lactation; response to copper ion; copper ion transport; transport;
	Sources:Amigo / QuickGO
Orthologs
	540
	11979
	ENSG00000123191
	ENSMUSG00000006567
	P35670
	Q64446
	NM_000053; NM_001005918; NM_001243182; NM_001330578; NM_001330579
	NM_007511
NP_000044; NP_001005918; NP_001230111; NP_001317507; NP_001317508;
	NP_000044.2; NP_000044.2; NP_001005918.1; NP_001230111.1
	NP_031537; NP_001390638
	Wikidata
View/Edit Human	View/Edit Mouse

Wilson disease protein (WND), also known as ATP7B protein, is a copper-transporting P-type ATPase which is encoded by the ATP7B gene. The ATP7B protein is located in the trans-Golgi network of the liver and brain and balances the copper level in the body by excreting excess copper into bile and plasma. Genetic disorder of the ATP7B gene may cause Wilson's disease, a disease in which copper accumulates in tissues, leading to neurological or psychiatric issues and liver diseases.